Science & Technology

State Grant will Support Hingorani’s Research on Lynch Syndrome

Manju Hingorani

Manju Hingorani

Manju Hingorani, professor of molecular biology and biochemistry, received a grant worth $324,127 from the State of Connecticut Department of Public Health on May 1.

Hingorani will use the grant to address an important need for new diagnostic technology for Lynch Syndrome (LS), a genetic disorder involving malfunction of DNA mismatch repair, which substantively increases the risk of colorectal, endometrial and other cancers. About 150,000 patients are diagnosed with colon cancer in the U.S. per year, of whom more than one in 35 have LS, and three or more of their relatives are at risk for the disorder (about one in 500 Connecticut residents).

“Early diagnosis of LS can profoundly affect the way in which cancer patients are treated—with respect to surgery, chemotherapy and future surveillance—and provide analogous benefits to their family,” Hingorani explained.

Current validated tests for LS have limitations that lower their feasibility and widespread use in screening at-risk populations.

“Our hypothesis is that the core functions of MMR proteins can be measured directly, quantitatively, rapidly, reliably and at clinically relevant protein concentrations on a nano-structured surface,” she said.

This project, proposed in collaboration by investigators Hingorani and Prabir Patra, assistant professor of mechanical engineering and director of the Biomedical Engineering Program at the University of Bridgeport, is expected to enable development of novel diagnostic nanosensors that will enable substantive advances in the screening, diagnosis and treatment of colorectal and other cancers.

Craighead’s Paper Published in Macroeconomics Journal

Bill Craighead

Bill Craighead

Bill Craighead, assistant professor of economics, is the author of a paper titled “Monetary Rules and Sectoral Unemployment in Open Economies” published in the June 2014 issue of the Journal of Macroeconomics.

Search theory has given us a more realistic mechanism to study unemployment in macroeconomic models. In this paper, Craighead integrated search theory into an “open economy” macroeconomic model – i.e., a model of an economy that interacts with the rest of the world.  One important question in open economy models is what measure of inflation should monetary policy respond to – consumer prices, which include imported goods, or producer prices (the prices of domestically-produced output).  In this model, Craighead shows that monetary policies that focus on producer prices do a better job of stabilizing unemployment.

New Assessment: Climate Change is Here and Now

Gary YoheOn May 6, the Obama Administration released its most comprehensive analysis to date about the impact of the human activity on the climate in the National Climate Assessment, of which Huffington Professor of Economics and Environmental Studies Gary Yohe is vice chair of the Development and Advisory Committee. The report concludes with more certainty than ever that climate change is affecting the daily lives of Americans right now through increases in extreme weather, sea level rise, heat, heavy downpours, drought and other adverse conditions.

PBS Newshour covered the release of the report. Speaking at a press conference at the White House, Yohe said, “What keeps me up at night is a persistence across the population not to recognize that the old normal climate is broken, and we don’t know what the new normal climate is going to be. That lack of recognition and the inability of this community and decision-makers to communicate those risks to individuals unnecessarily puts economic assets at risk, unnecessarily puts human lives at risk, unnecessarily puts ecosystems at risk.”

Yohe also spoke to The Associated Press about the assessment, explaining that this final report is a re-written and shortened version of the draft that was released in January 2013, with more scientific references, reviews by experts and the public, and a thorough review by the National Academy of Sciences. There is even stronger evidence now of climate change than there was in 2013, he said.

And Yohe told NBC News that at a personal level, “…everybody can look out their window and see something about their climate that has changed over the last 5, 10 or 15 years.”

In addition, Mother Jones quotes Yohe as saying: “One major take-home message is that just about every place in the country has observed that the climate has changed…It is here and happening, and we are not cherry-picking or fear-mongering.”

Yohe was also interviewed by Voice of Russia UK radio.

Watch the full White House press conference on C-SPAN.

 

 

Kopac, Herbst, Martinez MA ’13 Attend Space Telescope Science Institute Symposium

Biology Ph.D candidate Sarah Kopac was invited to speak at the 2014 Spring Symposium of the Space Telescope Science Institute on the campus of Johns Hopkins University in Baltimore, M.D. on April 29. Kopac spoke on “Specialization of Bacillus in the Geochemcially Challenged Environment of Death Valley.” Watch a video of her 20 minute presentation online here.

Kopac’s talk was part of a four-day interdisciplinary meeting titled “Habitable Worlds Across Time and Space” featuring speakers from around the world working in such diverse fields as biology, geology and astronomy. The focus of the seminar was on identifying places within our Solar System and Galaxy where we can most profitably search for life beyond the Earth.

Astronomy major Raquel Martinez, MA ’13 and William Herbst, the John Monroe Van Vleck Professor of Astronomy, director of graduate studies, also attended the conference.

Both Kopac and Martinez were active active participants in Wesleyan’s Planetary Science Group seminars and activities. Kopac’s advisor is Fred Cohan, professor of biology, professor of environmental studies. Martinez’s advisor was Seth Redfield, assistant professor of astronomy.

Biology Ph.D candidate Sarah Kopac speaks at the the Space Telescope Science Institute's Spring Symposium.

Biology Ph.D candidate Sarah Kopac speaks at the the Space Telescope Science Institute’s Spring Symposium.

Raquel Martiniz MA '13 poses with her research poster and conference organizer John Debes. Raquel is currently working in NASA's Goddard Spaceflight Center and has been accepted to the Ph.D. program at the University of Texas where she will begin studies in the fall.

Raquel Martiniz MA ’13 poses with her research poster and conference organizer John Debes. Raquel is currently working in NASA’s Goddard Spaceflight Center and has been accepted to the Ph.D. program at the University of Texas where she will begin studies in the fall.

Hughes Receives NSF Grant for Research on Planetary Systems

Meredith Hughes

Meredith Hughes

Meredith Hughes, assistant professor of astronomy, received a grant from the National Science Foundation to support her research on “Dust and Gas in Debris Disks Reveal the Origins of Planetary Systems.” The grant, awarded on April 21, is worth $532,943.

Hughes’ research focuses on understanding the formation and evolution of planetary systems.  She particularly studies the huge disks of gas and dust surrounding a young star, which can give insight into how and when a star planet might form. The disk is made up of  “junk” left over from the star’s formation.

The main technique Hughes uses to observe these circumstellar disks involves collecting radio waves. Invisible to the human eye, radio light allows astronomers to peer into dense dust clouds and trace the motions of small molecules.

Read more about Hughes’ research on planetary system formation in these past articles:

http://newsletter.blogs.wesleyan.edu/2014/03/06/hughesscience/
http://newsletter.blogs.wesleyan.edu/2013/05/26/hughes/

Oliver Honored with NIH Award for Protein Translocation Research

Don Oliver

Don Oliver

Professor Don Oliver received a three-year grant from the National Institutes of Health (NIH) Academic Research Enhancement Award (AREA) (R15) for his research titled “Mechanism of SecA-dependent protein translocation.” The grant, worth $374,148, was awarded on April 15.

Oliver is the Daniel Ayres Professor of Biology and professor of molecular biology and biochemistry.

Oliver studies how proteins are targeted to and transported across biological membranes utilizing bacteria as a simple model system.”The current genetic and biochemical studies are designed to elucidate a molecular motor protein, SecA ATPase, that drives proteins through a universally conserved protein-conducting channel by a largely unknown molecular mechanism,” he said.  “Clarification of the transport mechanism by this motor and its interplay with the channel is essential for understanding comparable protein transport systems in higher cells.”

In addition, such studies should allow for the development of novel antibacterial agents against SecA in order to combat the spread of multi-drug resistant bacterial pathogens.

The grant funds will be utilized to support two Ph.D. Students, a BA/MA fifth-year student, and four undergraduate research students that comprise of Oliver’s research group.

NASA Supports Greenwood’s Research on the Moon’s Water

James “Jim” Greenwood

James “Jim” Greenwood

Assistant Professor of Earth and Environmental Sciences James “Jim” Greenwood has received a $331,000 grant from NASA to support his research on the moon’s water.

His proposed research, tracking water in rock samples brought back by the Apollo missions, will “take a giant leap towards solving one of the most important questions in planetary science – whether the Moon is wet or dry,” Greenwood said.

“We’ll be studying pockets of glass trapped in early and late-crystallizing minerals in lunar mare basalt samples,” Greenwood said. “We will measure water and other volatile elements in these trapped melt pockets to reconstruct the volatile history of the samples as they cooled and crystallized near the lunar surface.”

The NASA grant is part of NASA’s Lunar Advanced Science and Exploration Research program.

Greenwood intends to use the grant, which will be distributed over four fiscal years, to fund one Wesleyan undergraduate per summer to conduct research in his lab. The grant will also allow Greenwood to do critical measurement work at Hokkaido University in Sapporo, Japan.

This project is only the latest initiative in Greenwood’s intensive work on lunar rocks, and the Moon’s relative wetness. Most recently he and four colleagues co-authored a paper in the prestigious journal Science, casting doubt on the theory of abundant lunar water, while simultaneously boosting theories around the Moon’s creation, several billion years ago.

 

Petit Family Foundation Supports Green Street’s Science Summer Camp

A summer science camp for girls – featuring three Wesleyan faculty, several Wesleyan students and two teaching artists – will be supported by a new $10,000 grant from the Petit Family Foundation. The camp, a pilot program of the Green Street Arts Center, will expose about 10 local 5th grade girls to “real world examples of women in science” and introduce them to the wide variety of scientific careers.

“We still have a long way to go to achieve gender equality in STEM (science, technology, engineering and math) fields,” said Sara MacSorley, Green Street’s director. “We want to support young girls in our community. A key piece to increasing the number of women in the sciences is to provide role models and support systems.”

The idea for the camp was born out of conversations MacSorley had last year with several Wesleyan faculty around connecting the PIMMS (Project to Increase Mastery of Mathematics and Science) program at Green Street to research going on in campus labs.

Those faculty – Erika Taylor, assistant professor of chemistry, assistant professor of environmental studies;  Christina Othon, assistant professor of physics; and Ruth Johnson, assistant professor of biology — will teach in the camp, assisted by Wesleyan students from their respective departments. Teaching artists Lindsay Behrens and Meredith Arcari, who work in Green Street’s Science and Art AfterSchool Program, will help include the arts integration approach to learning science concepts.

The campers will be chosen from among the current AfterSchool students at Green Street. With the help of the Wesleyan teaching assistants , they’ll do hands-on experiments, art projects and a final science show for family and friends.

“An evaluation piece – this is really cool – will be to have the girls draw a picture of a scientist at the very beginning, before they interact with any of the faculty or students,” MacSorley said. “Then at the end of the week, we’ll ask them to complete the same task. This exercise has been done in other places with surprisingly diverse results.”

The Green Street project was chosen from among 40 proposals this year to the Petit Family Foundation. To read more about the foundation go here.

 

Cognitive Development Lab Designs Games for Family Math Night

Wesleyan’s Cognitive Development Labs hosted Family Math Night at Edna Stevens Elementary School in Cromwell, Conn. on April 9. The event was full of games and activities for preschool children to play and get them excited about math while showing families activities that they can do at home to prepare their children for kindergarten. Assistant Professor of Psychology Anna Shusterman’s students designed the math games as part of a research methods class.

Students of Anna Shusterman designed math games for Edna Stevens Elementary School’s Family Math Night. Pictured here are (top from left) Elissa Palmer ’16, Tawni Stoop ’15, Jess Taggart, Anna Shusterman, Max, Alison Denzer-King ’16, Davey Bales ’15, Olivia Mason 15, Julia Vermeulen ’15, Maddy Oswald ’14, Maddy Kidd ’14, and Reuben. Taggart is the lab coordinator for the Cognitive Development Lab’s and Max and Reuben are Professor Shusterman’s sons.

Students of Anna Shusterman designed math games for Edna Stevens Elementary School’s Family Math Night. Pictured here are (top from left) Elissa Palmer ’16, Tawni Stoop ’15, Jess Taggart, Anna Shusterman, Max, Alison Denzer-King ’16, Davey Bales ’15, Olivia Mason 15, Julia Vermeulen ’15, Maddy Oswald ’14, Maddy Kidd ’14, and Reuben. Taggart is the lab coordinator for the Cognitive Development Lab’s and Max and Reuben are Professor Shusterman’s sons.

Northrop Awarded Prestigious NSF CAREER Award

Brian Northrop

Brian Northrop

This month, the National Science Foundation awarded Brian Northrop, assistant professor of chemistry, with a 2014 Faculty Early Career Development (CAREER) award.

The CAREER awards support junior faculty who exemplify the role of teacher-scholars through outstanding research, excellent education and the integration of education and research within the context of the mission of their organizations.

The honor came with a five-year grant totaling $537,561, which Northrop will use on his study titled “Selective Thiol-Ene and Thiol-Yne Chemistry, From First Principles to Organic Materials.”

At Wesleyan, Northrop’s research focuses on the design, synthesis and analysis of new organic materials utilizing molecular recognition and self-assembly, and “click” chemistry. With the CAREER Award, Northrop and his students will continue to investigate new methods for making polymers and nanoscale assemblies.

“Synthetic polymers form the basis of many of the materials we encounter every day, from plastics and adhesives to medical equipment and electronics,” Northrop explained. “One of the primary goals of contemporary polymer synthesis is to be able to fine-tune the physical properties of polymers by exhibiting precise control over their chemical structure. By developing methods that allow such precise control, researchers are able to directly influence whether a given polymer is stiff or flexible, fragile or resilient, insulating or conductive, etc.”

Much of the research in Northrop’s lab focuses on developing a thorough, fundamental understanding of how compounds known as thiols react with alkenes and alkynes.

After Studying Abroad, Mummini ’14 Hired as Health Programs Assistant in Denmark

Swetha Mummini ’14

Swetha Mummini ’14 is a biology and neuroscience and behavior double major.

In this issue of The Wesleyan Connection, we speak with Swetha Mummini ’14 who studied abroad last spring through the Danish Institute for Study Abroad Program. Her study abroad program hires two graduating past participants to be paid interns for the year after graduation and Mummini received the internship for the science and health programs assistant. 

Q: What prompted you to study abroad in Copenhagen?

A: Macaroni and cheese. I know that sounds a bit ridiculous, but the first time I seriously considered going abroad was at the very beginning of junior year when my friend Catherine invited her friends over for baked macaroni and cheese. Over the course of the meal, her friends talked about their plans to go abroad during spring semester of junior year, and that moment served as my personal eureka moment. I realized what a unique opportunity studying abroad was and how I should take the opportunity to pursue it. That night, I was up until 4 a.m. researching programs and trying to find the perfect fit. Denmark has always fascinated me, especially because of its status as the happiest country in the world and its welfare state. The program that I chose, the Danish Institute for Study Abroad (DIS), also offered a wide variety of health science and public health classes that appealed to me.

Q: What did you like about the DIS program in particular?

A: For premedical students, DIS has a unique program called Medical Practice and Policy. It’s a very hands-on program that exposes students to the fundamentals of clinical medicine and the European healthcare system. By participating in the program, I was able to get clinical exposure that I wouldn’t necessarily be able to experience in the U.S. I learned how to take a patient’s case history and formulate a diagnosis. I also learned how to perform basic medical procedures, such as taking an ultrasound and drawing blood. To give students a broader understanding of healthcare policy, our class also took a weeklong trip to Vienna and Budapest where we heard from physicians and other medical specialists about the challenges in their healthcare systems.