Tag Archive for Chemistry

Fry’s Article Published in Tetrahedron

Albert Fry, the E.B. Nye Professor of Chemistry, is the co-author of “Substituent Effects on the Redox Properties and Structure of Substituted Triphenylamines. An Experimental and Computational Study,” published in Tetrahedron, 65, 2408-2414, 2009.

Northrop Co-Authors Several Articles in Chemistry Journals

Brian Northrop, assistant professor of chemistry, is the co-author of several new articles. These include: “Ultrafast Optical Excitations In Supramolecular Metallacycles with Charge Transfer Properties,” published in Journal of the American Chemical Society, 132, 1348-1358 in 2010; “Assembly of Metallacycles on HOPG by Shape-Persistent Macrocycle Templates,” published in Journal of the American Chemical Society, 132, 1328-1333, 2010; “Surface Confined Metallosupramolecular Architectures: Formation and Scanning Tunneling Microscopy Characterization,” published in Accounts of Chemical Research, 42, 249-259, 2009; “Directed Self-Selection in the Coordination-Driven Self-Assembly of Irregular Supramolecular Polygons,” published in Journal of Organic Chemistry, 74, 3554-3557, 2009.

Also, “Synthesis of Six-Component Metallodendrimers via [3+3] Coordination-Driven Self-Assembly,” published in the Journal of Organic Chemistry, 74, 3524-3527, 2009; “Introduction of Heterofunctional Groups onto Molecular Hexagons via Coordination-Driven Self-Assembly,” published in the Journal of Organic Chemistry 74, 4828-4833, 2009; “Facile Self-Assembly of Neutral Dendritic Metallocycles via Oxygen-to-Platinum Coordination,” published in the Journal of Organic Chemistry, 74, 7067-7074, 2009; “Self-Organization in Coordination-Driven Self-Assembly,” published in Accounts of Chemical Research, 42, 1554-1563, 2009; and “Synthesis and X-ray structural analysis of platinum and ethynyl-platinum corannulenes: supramolecular tectons,” published in Organic and Biomolecular Chemistry, 7, 2009.

Pratt Published in Bioorganic Chemistry Publication

Rex Pratt, the Beach Professor of Chemistry, is the co-author of  “Substituted aryl malonamates as new serine b-lactamase substrates: Structure-activity studies,” published in Bioorganic & Mecicinal Chemistry,18, 282 in 2010; “Approaches to the simultaneous inactivation of metallo- and serine- b-lactamases,” published in Bioorganic & Medicinal Chemistry Letters,19, 1618; 2009; “Inhibition of class A and C b-lactamases by diaroyl phosphates,” published in Biochemistry, 48, 8285, 2009; “Intramolecular cooperativity in the reaction of diacyl phosphates with serine b-lactamases,” published in Biochemistry, 48, 8293, 2009; “Structural basis of the inhibition of class A b-lactamases and penicillin-binding proteins by 6-b-iodopenicillanate,” published in the Journal of the American Chemical Society, 131, 15262, in 2009.

5 Questions With . . . Erika Taylor

Erika Taylor, assistant professor of chemistry, is exploring lignin as a possible carbon source of biofuel. (Photo by Bill Burkhart)

In this issue, we ask 5 Questions to. . . Erika Taylor, assistant professor of chemistry and chair of the 35th Peter A. Leermakers’ Committee.

Q. How did you get involved in biofuel research?

A.There seemed to be a compelling need for more scientists to look for alternatives to biofuel carbon sources beyond the ones that have already been researched, corn being a common, but problematic one.

Q. Can you explain what lignin is?

A. Lignin is the second most abundant polymer on the planet (the most abundant polymer is cellulose). Lignin is interwoven into trees, along with cellulose and hemicellulose, two sugar polymers. Lignin provides the structural rigidity.

Q. Why are you exploring lignin as a possible carbon source of biofuel?

A. more than 50 millions tons of lignin are produced each year. It  is an abundant waste product of both the biofuel and paper industries. Lignin is also found in municipal waste. My hope is to take the lignin and develop a means for recycling it into a biofuel

Students, Alumni Present Research at Biophysical Meeting in San Francisco

Several Wesleyan students presented their work at the Biophysical Society 54th Annual Meeting Feb. 20-24 in San Francisco, Calif. More than 6,000 scientists from academia, government and industry attended. Olga Buzovetsky '10, pictured, presented her poster titled "Binding and Bending Parameters of Integration Host Factor to Holliday Junction." Her advisor is Ishita Mukerji, professor of molecular biology and biochemistry.

Several Wesleyan students and recent alumni presented their work at the Biophysical Society 54th Annual Meeting Feb. 20-24 in San Francisco, Calif. More than 6,000 scientists from academia, government and industry attended. Olga Buzovetsky '10, pictured, presented her poster titled "Binding and Bending Parameters of Integration Host Factor to Holliday Junction." Her advisor is Ishita Mukerji, professor of molecular biology and biochemistry.

Graduate student Sanchaita Das presented her poster titled, "Mapping SecA-SecY Interaction using In Vivo Photo-Cross Linking." Das's advisor is Don Oliver, the Daniel Ayres Professor of Biology, professor of molecular biology and biochemistry.

Graduate student Sanchaita Das presented her poster titled, "Mapping SecA-SecY Interaction using In Vivo Photo-Cross Linking." Das's advisor is Don Oliver, the Daniel Ayres Professor of Biology, professor of molecular biology and biochemistry.

NSF Awards Grant to Dierker, Beveridge

Lisa Dierker, chair and professor of psychology, and David Beveridge, the University Professor of the Sciences and Mathematics, professor of chemistry, received a $174,999 grant from the National Science Foundation. The grant will support an inquiry based, supportive approach to statistical reasoning and applications. The award will be applied Jan. 1, 2010 through Dec. 31, 2012.

Grant to Support Chemistry Department Fume Hoods

The Chemistry Department received a $125,000 grant from the George I. Alden Trust of Worcester, Mass. on Oct. 21. The funds will be used to replace, reconfigure, and add fume hoods in a teaching lab used for introductory chemistry courses.

Bolton Receives NIH Grant for DNA Research

Philip Bolton, professor of chemistry, received a grant for $76,037 from the National Institutes of Health’s National Institute of General Medical Sciences. The grant, awarded on Sept. 30, is for research titled “Structures and Complexes of Vertebrate Telomere Repeat DNAs.” This is a Supplemental Recovery Act Award.

Faculty, Students Present Research at Molecular Biophysics Program

Manju Hingorani, associate professor of molecular biology and biochemistry, speaks on DNA mismatch repair during the 10th annual Molecular Biophysics Program Sept. 24 at Wadsworth Mansion in Middletown. More than 70 students and faculty attended the day-long event.

Manju Hingorani, associate professor of molecular biology and biochemistry, speaks on DNA mismatch repair during the 10th annual Molecular Biophysics Program Sept. 24 at Wadsworth Mansion in Middletown. More than 70 students and faculty attended the day-long event.

Wilma Olson, the Mary I. Bunting Professor of Chemistry at Rutgers University, was the keynote speaker. She spoke about DNA Mechanics and Regulation. Olson is an expert on the influence of chemical architecture on the structure and properties of nucleic acids.

Wilma Olson, the Mary I. Bunting Professor of Chemistry at Rutgers University, was the keynote speaker. She spoke about DNA Mechanics and Regulation. Olson is an expert on the influence of chemical architecture on the structure and properties of nucleic acids.

At left, Michael Weir, director of the Hughes Program in the Life Sciences, professor of biology, and in center, Brian Northrop, assistant professor of chemistry, listen to Olson's presentation.

At left, Michael Weir, director of the Hughes Program in the Life Sciences, professor of biology, and in center, Brian Northrop, assistant professor of chemistry, listen to Olson's presentation.

Northrop also delivered a talk during the retreat titled 'Dynamic self-assembly as a route to new organic materials.'

Northrop also delivered a talk during the retreat titled 'Dynamic self-assembly as a route to new organic materials.'

During a poster session, molecular biology and biochemistry graduate student F. Noah Biro explains his DNA mismatch repair research titled "Developing Reporter Systems to Monitor the Structural Dynamics of MutS." Biro's faculty advisor is Manju Hingorani.

During a poster session, molecular biology and biochemistry graduate student F. Noah Biro explains his DNA mismatch repair research titled "Developing Reporter Systems to Monitor the Structural Dynamics of MutS." Biro's faculty advisor is Manju Hingorani.

Laurel Appel, director of the McNair Program, adjunct associate professor of biology, senior research associate, listens to Biro explain his research.

Laurel Appel, director of the McNair Program, adjunct associate professor of biology, senior research associate, listens to Biro explain his research.

Olson mingled with students during the Poster Session.

Olson mingled with students during the Poster Session.

Chemistry graduate student Daniel Czyzyk, center, explains his research titled "Heptosyltransferase I and its Role in Biofilm Formation." Czyzyk's advisor is Erika Taylor, assistant professor of chemistry.

Chemistry graduate student Daniel Czyzyk, center, explains his research titled "Heptosyltransferase I and its Role in Biofilm Formation." Czyzyk's advisor is Erika Taylor, assistant professor of chemistry.

David Beveridge, the University Professor of the Sciences and Mathematics, professor of chemistry, reads through the program schedule.

David Beveridge, the University Professor of the Sciences and Mathematics, professor of chemistry, reads through the program schedule.

Chemistry graduate student Sattanathan Paramasivan talks about his research titled "A mix and measure fluorescence screening assay for the exploration of selective quadruplex binders." Paramasivan's advisor is Philip Bolton, professor of chemistry.

Chemistry graduate student Sattanathan Paramasivan talks about his research titled "A mix and measure fluorescence screening assay for the exploration of selective quadruplex binders." Paramasivan's advisor is Philip Bolton, professor of chemistry.

Rich Olson, assistant professor of molecular biology and biochemistry, speaks on "Poring over the structural basis of Vibro cholerae cytolysin assembly."

Rich Olson, assistant professor of molecular biology and biochemistry, speaks on "Poring over the structural basis of Vibro cholerae cytolysin assembly."

Chemistry Department research assistant Elizabeth Wheatley, right, speaks to Olga Buzovetsky '10, about her research titled "A Molecular Dynamics Study of DNA Bending in the Integration Host Factor-DNA Complex." The complex of the protein IHF with oligometric DNA results in a highly-unusual structure in which the DNA is bent by nearly 180 degrees. Wheatley's advisor is David Beveridge.

Chemistry Department research assistant Elizabeth Wheatley, right, speaks to Olga Buzovetsky '10, about her research titled "A Molecular Dynamics Study of DNA Bending in the Integration Host Factor-DNA Complex." The complex of the protein IHF with oligometric DNA results in a highly-unusual structure in which the DNA is bent by nearly 180 degrees. Wheatley's advisor is David Beveridge.

Molecular biology and biochemistry graduate student Yan Li explains her research titled "Investigation of the Binding Interaction of S. cerevisiae MutS homologs MSH2-MSH6 and MSH4-MSH5 with Holliday Junctions." Yan's advisors are Ishita Mukerji, chair and professor of molecular biology and biochemistry, and Manju Hingorani. (Photos by Olivia Bartlett Drake and Manju Hingorani)

Molecular biology and biochemistry graduate student Yan Li explains her research titled "Investigation of the Binding Interaction of S. cerevisiae MutS homologs MSH2-MSH6 and MSH4-MSH5 with Holliday Junctions." Yan's advisors are Ishita Mukerji, chair and professor of molecular biology and biochemistry, and Manju Hingorani. (Photos by Olivia Bartlett Drake and Manju Hingorani)

Bolton Receives NIH Grant for Gene Expression Research

Philip Bolton

Philip Bolton

Philip Bolton, professor of chemistry, received a grant for $331,800 from the National Institute of Health on Drug Abuse for his research on “Finding Small Molecules that Modulate Gene Expression.”

The grant, awarded on Sept. 1, spans for two years.

NIH Awards Pratt Grant for Active Site Chemistry

Rex Pratt

Rex Pratt

Rex Pratt, the Beach Professor of Chemistry, received a grant for $414,750 from the National Institute of Health and the American Recovery and Reinvestment Act of 2009. The continuation grant was awarded July 30. Pratt’s research is titled “Beta-Lactamases & DD-Peptidases: Active site Chemistry.”

Students Learn Teaching Tips at Professional Development Workshop

Noreen Nkosana '11 akes notes during the Professional Development Workshop July 24 in Daniel Family Commons. The workshop was designed for students who are considering careers in academia.

Noreen Nkosana '11 takes notes during the Professional Development Workshop July 24 in Daniel Family Commons. The workshop was designed for students who are considering careers in academia.

Pedagogy expert James Zimmerman, center, from Montclair State University taught the workshop.

Pedagogy expert and associate professor of chemistry James Zimmerman, center, from Montclair State University and Erika Taylor, assistant professor of chemistry, co-taught the two-part workshop.

Chemistry graduate student Jessica Fedorchick, center, learns pedagogical and curricular tools used to pique students' curiosity in the classroom.

Chemistry graduate student Jessica Fedorchick, center, learns pedagogical and curricular tools used to pique students' curiosity in the classroom.

Biology graduate student Jiang "Shannon" Liu, was one of the graduate and advanced undergraduate students who learned "how to teach" with theory and examples.

Biology graduate student Jiang "Shannon" Liu, was one of the graduate and advanced undergraduate students who learned "how to teach" with theory and examples. This was the second year Wesleyan hosted the workshop. The workshop is supported by a Seed Grant from the Pedagogical Renewal Committee and the Hughes program. (Photos by Olivia Bartlett Drake)