Tag Archive for biochemistry

Hot off the Press: New Papers by Hingorani, Tucker, Case PhD ’19

Manju Hingorani, visiting scholar in molecular biology and biochemistry, and Brandon Case PhD ’19 are co-authors of a new study published in Proceedings of the National Academy of Sciences USA in July 2020. The paper, titled “Recurrent mismatch binding by MutS mobile clamps on DNA localizes repair complexes nearby,” reports novel findings about the mechanism whereby MutS protein triggers initiation of DNA repair. The research at Wesleyan was supported by NIH grant R15 GM114743 awarded to Manju Hingorani. Case is currently a postdoctoral fellow at Harvard Medical School.

Jennifer Tucker, associate professor of history, discusses the role of material culture and visual media in shaping how museums communicate histories of science and technology in an article titled “Guns, Germs, and Public History: A Conversation with Jennifer Tucker,” published July 8, 2020 in the Journal of The History of the Behavioral Sciences.

Faculty, Alumni, Students Publish Books, Journal Articles

Several faculty have recently authored or co-authored books, book chapters, and articles that appear in prestigious academic journals.

BOOKS AND BOOK CHAPTERS

books

Eric Charry, professor of music, is the author of A New and Concise History of Rock and R&B through the Early 1990s (Wesleyan University Press, 2020).

Robert “Bo” Conn, professor of Spanish, is the author of Bolívar’s Afterlife in the Americas: Biography, Ideology, and the Public Sphere (Palgrave Macmillan, 2020).

Anthony Ryan Hatch, associate professor of science in society, is the author of three book chapters:
“The Artificial Pancreas in Cyborg Bodies,” published in The Oxford Handbook of the Sociology of the Body and Embodiment (Oxford University Press, 2020.) Sonya Sternlieb ’18 and Julia Gordon ’18 are co-authors.

“Against Diabetic Numerology in a Black Body, or Why I Cannot Live by the Numbers,” published in Body Battlegrounds: Transgressions, Tensions, and Transformations (Vanderbilt University Press, 2019).

“Food Sovereignty and Wellness in Urban African American Communities,” published in Well-Being as a Multi-Dimensional Concept: Understanding Connections between Culture, Community, and Health (Lexington Books, 2019). Deja Knight ’18 is a co-author.

James McGuire, professor of government, is the author of Democracy and Population Health (Cambridge University Press, 2020).

JOURNAL ARTICLES 
Three Wesleyan faculty, three recent alumni, and one undergraduate collaborated on an interdisciplinary study titled “A Ribosome Interaction Surface Sensitive to mRNA GCN Periodicity,” published in the journal Biomolecules, June 2020.

The co-authors include Michael Weir, professor of biology; Danny Krizanc, Edward Burr Van Vleck Professor of Computer Science; and Kelly Thayer, assistant professor of the practice in integrative sciences; William Barr ’18 MA ’19; Kristen Scopino ’19; Elliot Williams ’18, MA ’19; and Abdelrahman Elsayed ’21.

Barr and Williams worked on the project as a part of their BA/MA program.

Anthony Ryan Hatch is the author of three journal articles:
Du Boisian Propaganda, Foucauldian Genealogy, and Antiracism in STS Research,” published in Engaging Science, Technology, and Society, 2020.

Sugar Ecologies: Their Metabolic and Racial Effects,” published in 22 Food, Culture, and Society, 2019. Sonya Sternlieb ’18 and Julia Gordon ’18 are co-authors.

Two Meditations in Coronatime,” published by the Section on Science, Knowledge, and Technology of the American Sociological Association, May 2020.

Jennifer Tucker, associate professor of history, is featured in the article “Guns, Germs, and Public History: A Conversation with Jennifer Tucker,” published by the Journal of the History of the Behavioral Sciences, July 2020.

Margot Weiss, associate professor of anthropology, associate professor of American studies, is the author of “Intimate Encounters: Queer Entanglements in Ethnographic Fieldwork,” published in Anthropological Quarterly, Volume 93, June 2020, and “Hope and Despair in the Queer Nonprofit Industrial Complex,” published in the GLQ: A Journal of Lesbian and Gay Studies, Volume 26, April 2020.

Faculty Publish Books, Journal Articles

Several faculty have recently authored or co-authored books, book chapters, and articles that appear in prestigious academic journals.

BOOKS AND BOOK CHAPTERS

barnhart book

Book by Joslyn Barnhart

fusso book

Book translated by Susanne Fusso

weilbook

Book by Kari Weil

Joslyn Barnhart, assistant professor of government, is the author of The Consequences of Humiliation: Anger and Status in World Politics (Cornell University Press, 2020).

Susanne Fusso, Marcus L. Taft Professor of Modern Languages, is the translator of The Nose and Other Stories by Nikolai Gogol (Columbia University Press, 2020).

Ruth Johnson, associate professor of biology, is the author of a book chapter titled “Adhesion and the Cytoskeleton in the Drosophila Pupal Eye,” published in the book Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye (Springer Science and Business Media, 2020).

Elizabeth McAlister, professor of religion, is the author of a chapter titled “Sacred Waters of Haitian Vodou: The Pilgrimage of Sodo,” published in Sacred Waters: A Cross-Cultural Compendium of Hallowed Springs and Holy Wells (Routledge, 2020).

Kari Weil, University Professor of Letters, is the author of the book Precarious Partners: Horses and Their Humans in Nineteenth-Century France (University of Chicago Press, 2020). She also wrote a book chapter titled “The Animal Novel That Therefore This Isn’t,” published in New Approaches to the Twenty-FirstCentury Anglophone Novel (Palgrave MacMillan, 2019).

 

JOURNAL ARTICLES

Lindsay Dolan, assistant professor of government, is the author of “Rethinking Foreign Aid and Legitimacy: Views from Aid Recipients in Kenya,” which was published in Studies in Comparative International Development 55(2) in 2020.

Ruth Johnson, associate professor of biology, and Joe Coolon, assistant professor of biology, are co-authors of “Mask, a Component of the Hippo Pathway, is Required for Drosophila Eye Morphogenesis,” published in Developmental Biology in August 2020. The study also is featured on the cover of Issue 464.

Bill Johnston, professor of history, is the author of “Epidemic Culture in Premodern Japan,” published June 23 by the Society for Cultural Anthropology, from the Series “Responding to an Unfolding Pandemic: Asian Medicines and Covid-19.”

Robert Lane, associate professor and chair of molecular biology and biochemistry, is the author of “Bioinformatics discovery of putative enhancers within mouse odorant receptor gene clusters,” published in Chemical Senses, 44(9), 2019.

Ioana Emy Matesan, assistant professor of government, is the author of “Grievances and Fears in Islamist Movements: Revisiting the Link between Exclusion, Insecurity, and Political Violence,” published in the Journal of Global Security Studies in 2020.

Ishita Mukerji, Fisk Professor of Natural Science and professor of molecular biology and biochemistry, and Manju Hingorani, visiting scholar in molecular biology and biochemistry, are the co-authors of “Mismatch Recognition by Msh2-Msh6: Role of Structure and Dynamics,” published in the International Journal of Molecular Sciences on Aug. 31, 2019.

Anna Shusterman, associate professor of psychology, is the co-author of “Working in the Research-to-Practice Gap: Case Studies, Core Principles, and a Call to Action,” published in PsyArXiv on Sept. 23, 2019. Six Wesleyan students also are co-authors of the article.

Justine Quijada is the author of “From Culture to Experience: Shamanism in the Pages of the Soviet Anti-Religious Press,” published in Contemporary European History, Vol. 29, Special Issue 2 (Religion and Socialism in the Long 1960s: From Antithesis to Dialogue in Eastern and Western Europe), 2020.

View all faculty publications online here.

Graduate Students, Faculty Attend Yeast Genetics Meeting

From the left is Anna Rogers and Lorencia Chigweshe, both graduate students in the Molecular biology and Biochemistry program.

Graduate students Anna Rogers and Lorencia Chigweshe presented their poster at the GSA meeting.

Two Wesleyan graduate students and two faculty members presented posters at the GSA Yeast Genetics and Molecular Biology Meeting held at Stanford University on Aug. 22–26. This meeting, which is held once every two years, is organized by the Genetics Society of America (GSA). The meeting brings together hundreds of scientists making groundbreaking discoveries in the field of genetics and gene regulation using the innovative power of yeast genetics.

Both students received a travel grant through Wesleyan’s Melnick Fund to support travel to the conference.

Lorencia Chigweshe presented a poster titled “Interactions between histone variant H2A.Z and linker histone H1 in Saccharomyces cerevisiae meiosis,” while Anna Rogers presented “The histone variant H2A.Z promotes chromosome condensation in Saccharomyces cerevisiae.” Both students are mentored by Scott Holmes, professor of molecular biology and biochemistry, whose lab investigates how the processes of chromosome segregation and gene expression are regulated in eukaryotes.

“We had the opportunity to engage with experts in the field of yeast genetics and learn from them and get insight on our own work,” Chigweshe said. “The conference was a great opportunity to appreciate yeast as a powerful tool for understanding genetics in addition to its industrial application in beer and bread-making.”

Amy MacQueen, associate professor of molecular biology and biochemistry, associate editor for Genetics, cochaired a workshop on scientific publishing and also presented a poster titled “Synapsis and recombination unite at the Zip1’s N-terminal tip” while Mike McAlear, associate professor of molecular biology and biochemistry, presented “Adjacent gene co-regulation (AGC) as a strategy for transcriptional control and coupling.” McAlear is also associate professor, integrative sciences, and Holmes is also professor, integrative sciences.

Students Inducted into Honor Society, Present Research at American Society for Biochemistry and Molecular Biology Meeting

Undergraduates from the Biology, Chemistry, and Molecular Biology and Biochemistry majors showed off their science at the 2018 meeting of the American Society for Biochemistry and Molecular Biology. From Left, Alex Shames '18 (MacQueen Lab), BA/MA student Arden Feil (MacQueen Lab), Will Barr '18 (Weir Lab), Christine Little '18 (Mukerji Lab), Cody Hecht '18 (Taylor Lab), and Emily Kessler '18 (Hingorani Lab).

Undergraduates from the biology, chemistry, and molecular biology and biochemistry majors showed off their science at the 2018 meeting of the American Society for Biochemistry and Molecular Biology. From left, Alex Shames ’18 (MacQueen Lab), Arden Feil BA/MA ’18 (MacQueen Lab), Will Barr ’18 (Weir Lab), Christine Little ’18 (Mukerji Lab), Cody Hecht ’18 (Taylor Lab), and Emily Kessler ’18 (Hingorani Lab).

Seven Wesleyan students recently were inducted into the American Society for Biochemistry and Molecular Biology (ASBMB) Honor Society, and many of them presented research posters at the ASBMB annual meeting in San Diego, April 21–25.

The ASBMB Honor Society recognizes exceptional undergraduate juniors and seniors who are pursuing a degree in the molecular life sciences for their scholarly achievement, research accomplishments, and outreach activities. The Wesleyan students inducted were Will Barr ’18, Alexa Strauss ’19, Emily Kessler ’18, Christine Little ’18, Julie McDonald ’18, Rubye Peyser ’18, and Alexander Shames ’18.

The following students attended the annual meeting:

• Kessler, whose poster was titled, “Investigating the Mechanistic Basis of Mutant MutS DNA Repair Protein Malfunction in Lynch Syndrome”
• Barr, “An mRNA-rRNA base pairing model for efficient protein translation”
• Little, “Investigation into the Binding Interactions of Saccharomyces cerevisiae Histone H1 with Holliday Junction”
• Shames, “The Long and Short of Synaptonemal Complex Assembly: Investigating the genesis and functional relevance of a smaller Zip1 isoform”
• Cody Hecht ’18, “Escherichia coli Heptosyltransferase I: Examining Protein Dynamics with Pyrene Excimer Fluorescence and Tryptophan-Induced Quenching”
• Arden Feil BA/MA ’18, “Scraping the Tip of Zip1’s Role in Meiotic Chromosome Dynamics: Using lacO/LacI corecruitment to identify crossover promoting factors that interface with the N-terminus of a synaptonemal complex protein”

“It was a joy to present the research that I’ve been working on for the past two years as a part of Wesleyan’s Beckman Scholars Program,” said Barr. “Science research can seem like a roller coaster at times, and presenting my research in the company of scientists at all levels of their careers helped me remember just how thrilling this process has been.”

The mission of ASBMB is to advance the science of biochemistry and molecular biology through organization of scientific meetings, advocacy for funding of basic research and education, support of science education at all levels, promotion of the diversity of individuals entering the scientific workforce, and publication of a number of scientific and educational journals, including the Journal of Biological Chemistry and the Journal of Lipid Research.

Case, Kessler ’18 Honored for Outstanding Poster Presentations

PhD candidate Brandon Case and Emily Kessler '18 attended the North Eastern Structural Symposium at the University of Connecticut.

PhD candidate Brandon Case and Emily Kessler ’18 attended the North Eastern Structural Symposium at the University of Connecticut.

Molecular Biology and Biochemistry PhD candidate Brandon Case and Emily Kessler ’18 recently won poster awards at the North Eastern Structural Symposium (NESS) at the University of Connecticut on Oct. 28.

Both students research the mechanisms of action of DNA replication and repair proteins with Manju Hingorani, chair and professor of molecular biology and biochemistry, professor of integrative sciences. Hingorani’s DNA Lab investigates proteins responsible for DNA replication and repair. These proteins maintain genome and cell integrity, and their malfunction leads to cancer and other diseases.

Case received an Outstanding Poster Award for his work, “Coordinated Actions of Four ATPase Sites on UvrA2 During Initiation of Nucleotide Excision Repair.”

Kessler, who is a Wesleyan Beckman Scholar, received an Outstanding Undergraduate Poster Award for “Investigating the MutS Conformational Dynamics During MMR Initiation of Lynch Syndrome-Linked MutS Mutants.” The NESS created this undergraduate award only for Kessler after hearing her presentation.

8 Faculty Awarded Tenure

In its recent meeting, the Board of Trustees conferred tenure on eight faculty members, effective July 1, 2015. They are: Associate Professor of Sociology Robyn Autry, Associate Professor of Government Sonali Chakravarti, Associate Professor of Molecular Biology and Biochemistry Amy MacQueen, Associate Professor of Music Paula Matthusen, Associate Professor of Molecular Biology and Biochemistry Rich Olson, Associate Professor of Mathematics Christopher Rasmussen, Associate Professor of Economics Damien Sheehan-Connor, and Associate Professor of Classics Eirene Visvardi.

Brief descriptions of their research and teaching appear below:

Associate Professor Autry is a cultural sociologist with broad interests in collective identity, memory, and visual culture. Her research on the ways in which the past is constructed and represented at museums has been published in several journals. Autry’s book, Desegregating the Past: The Public Life of Memory in South Africa and the United States, analyzes clashes around the development of history museums in both countries as a window into the desire for particular personal and collective orientations toward the past (Columbia University Press, forthcoming). She teaches courses on comparative race and ethnicity, the future, and memory and violence.

Hingorani Awarded Major NIH Research Grant

Manju Hingorani, professor of molecular biology and biochemistry, was awarded a grant of $408,609 from the National Institutes of Health (NIH) to study the structure and mechanisms of DNA repair proteins responsible for fixing errors in the genetic code and preventing carcinogenesis.

The three-year grant will fund PhD and undergraduate students’ research on DNA mismatch repair (MMR). MMR corrects base mismatches and loops in DNA, and is therefore a critical guardian of genetic and cellular integrity. Defects in this essential, evolutionarily conserved DNA repair process cause high levels of mutations in the genome, which in turn lead to cancer. In humans, MMR defects manifest most frequently in a hereditary disorder known as Lynch Syndrome (LS), which substantially raises the risk of colorectal, endometrial and many other cancers.

A large number of MMR defects occur due to small, single-amino-acid changes in the MutS protein that initiates the repair reaction. Hinagorani’s research group has been investigating MMR proteins for the past 15 years. The group now has a detailed enough understanding of the MutS biochemical mechanism to determine how changing single amino acids affects MutS structure and function enough to disrupt MMR. In addition to experimental research, the project also builds on computational modeling done in collaboration with Joshua Boger University Professor of the Sciences and Mathematics David Beveridge’s group in the Chemistry Department, and Professor Saraswathi Vishveshwara’s group at the the Indian Institute of Science in Bangalore, India. Beverage is also professor of chemistry. The researchers hope that by applying biochemical, biophysical and computational approaches in an interdisciplinary manner, students will gain new knowledge about MutS function and, thereby, a better understanding of the basis for its malfunction in cancer.

Olson Expert on X-ray Crystallography, Membrane Proteins

Rich Olson, assistant professor of molecular biology and biochemistry, is teaching a class on membrane properties, structural techniques and protein structure analysis.

Rich Olson, assistant professor of molecular biology and biochemistry, is teaching a class on membrane properties, structural techniques and protein structure analysis.

Rich Olson joined the Department of Molecular Biology and Biochemistry as an assistant professor.

Olson is an expert on X-ray crystallography and biophysical characterization of soluble/membrane proteins. He specifically studies the structure and function of membrane proteins in the nervous system, immunological molecules in the nervous system and structural biology of pathogen virulence factors.

This semester, he is teaching a course titled “Receptors, Channels, and Pumps: Advanced Topics in Membrane Protein Structure and Function,” and an individual undergraduate research tutorial.

When applying to Wesleyan, Olson says he was looking for an institution that would provide a balance between teaching and research.

“Wesleyan has a tradition of strong undergraduate education as well as a vibrant graduate program essential to supporting my research,” Olson says. “Having the graduate program allows me to tackle advanced research

NSF Supports Lane’s Research on Olfactory Receptor Gene Regulation

Robert Lane, associate professor of molecular biology and biochemistry, is researching a a complex odorant receptor gene regulatory system. (Photo by Olivia Drake)

Robert Lane, associate professor of molecular biology and biochemistry, is researching an odorant receptor gene regulatory system. (Photo by Olivia Bartlett Drake)

In order for animals to detect food sources, avoid predators and find mates, they rely on their olfactory system, or sense of smell.

The ability to detect and distinguish among thousands of environmental odorants is based on a combinatorial recognition system. A specific smell is coded in the brain by a specific combination of receptor proteins that get stimulated by the unique combination of odorant chemicals elicited by that scent.

“The smell of ‘lemons,’ for example, would result from a specific combination of odorant receptor proteins that become stimulated upon binding the specific set of inhaled chemicals emitted from a lemon,” explains Robert Lane, associate professor of molecular biology and biochemistry.

With support from the National Science Foundation (NSF), Lane will further investigate a complex odorant receptor gene regulatory system. His study, titled “Cross-Disciplinary Science & Investigation of Olfactory Receptor Gene Regulation” was funded with a two-year, $299,995 NSF grant

MacQueen Awarded $746,997 NIH Grant

Amy MacQueen, assistant professor of molecular biology and biochemistry, received a $746,997 grant from the national Institute of Health for her research titled “Regulation of Synaptonemal Complex Assembly During Meiosis in S. cerevisiae.” The grant, awarded Aug. 21, will be applied over three years.