Laura Grabel, the Lauren B. Dachs Professor of Science and Society, professor of biology, and Jan Naegele, professor of neuroscience and behavior, professor of biology, are the co-authors of “Migration of transplanted neural stem cells in experimental models of neurodegenerative diseases,” published in Stem Cells and Regenerative Medicine by Springer/Humana Press, 2010.
Tag Archive for Naegele
by Olivia Drake •
Janice Naegele, professor of biology, professor of neuroscience and behavior, is the co-author of “Gene and stem cell therapies for treating epilepsy,” published in Epilepsy: Mechanisms, Models, and Translational Perspectives, Dekker M, Inc., 2010; “Migration of transplanted neural stem cells in models of neurodegenerative diseases,” published in Stem Cells and Regenerative Medicine by Springer Science (Humana Press, 2010; “Westward Ho! Pioneering mouse models for X-linked infantile spasms syndrome,” published in Epilepsy Currents 10(1): 1-4, 2010; “Trekking through the telencephalon: hepatocyte growth factor-mediated guidance for parvalbumin-expressing interneurons,” published in Epilepsy Currents 10(4), 2010; and “Transplants for brain repair in epilepsy and neurodegenerative diseases,” published in Neuropharmacology 58: 855-864, 2010.
by David Pesci •
Ann Burke, associate professor of biology, recently received a three-year, $395,000 grant from the National Science Foundation (NSF) to study the development and evolution of the shoulder girdle using transgenic mice, frog and salamander.
The mice will be generated in collaboration with a lab at the University of Michigan and will allow Burke and her associates to turn off Hox genes, which are specific patterning genes, in specific sub populations of the embryonic mesoderm that make the musculoskeletal tissues.
“Comparing the dynamics of gene expression and cell interactions during the formation of the pectoral region in a variety of embryos will help us understand the evolution of these musculoskeletal structures and the dramatic variations among vertebrate lineages associated with adaptations for different locomotor strategies, like swimming, scurrying, crawling and flying,” Burke explains.
The frog and salamander experiments will use transplants of mesoderm between wild type embryos and embryos that have Green Fluorescent Protein (GFP) expressed in all their cells, allowing Burke and her associates to fate map mesodermal cell populations.
Fate mapping is determining which cellular structures in the embryo give rise to which adult structures.
“We do this by transplanting the embryonic structure from a labeled embryo (GFP in this case) into the same spot in an unlabeled embryo, and tracing the ‘fate’ of the labeled cells, that is which adult structure they end up in,” Burke says.
Burke also received a two-year $100,000 grant from the National Institutes of Health (NIH) to use the same amphibian systems (salamander and frog) to develop a model system for understanding body wall defects in humans.
The grants will provide funds for a team of researchers at Wesleyan working with Professor Burke on these projects, including a postdoctoral fellow, graduate students and undergraduates.
“Receiving these two new federal grants, plus a grant from the Eppley foundation earlier this year, is a remarkable accomplishment in any year, but particularly this year as funding levels have dropped precipitously,” says Jan Naegele, professor of biology, professor of neuroscience and behavior.
by Olivia Drake •
Jan Naegele, professor of neuroscience and behavior, professor and chair of biology, was honored for her innovative work in bioscience by the organization “We Work For Health” overseen by the Connecticut Consortium of Independent Colleges on May 18. Congressman Joe Courtney presented a plaque to Naegele’s designee, Deborah Hall ’11 at a ceremony in Cromwell, Conn.
by Olivia Drake •
Janice Naegele, professor of neuroscience and behavior, professor and chair of biology, is the co-recipient of a grant from the Fragile X Foundation worth $69,450 for the “Role of STEP in Fragile X Syndrome.” The grant was awarded May 1. Fragile X is the most common inherited cause of mental impairment and the most common known cause of autism. About 25 percent of children with Fragile X have seizures and epilepsy. The grant will support research on the causes and potential treatments for epilepsy in a mouse model of Fragile X. In addition to the grant, Professor Naegele and her collaborators were invited to participate in the FRAXA Research Foundation Investigators Meeting in September 2008 in Durham, N.H.