Oliver

All cells — bacterial or human — secrete up to 10 or 20 percent of the proteins that they make. Human secreted proteins, for example, include components of serum, hormones, growth factors that promote cell development during embryogenesis and tissue remodeling, and proteins that provide the basis for immune cell signaling during infection or when fighting cancer. The secretion process, however, isn't an easy feat for cells, as they need to move the proteins across a membrane through a channel. Transport requires the formation of a hairpin, formed by an initiator protein. In a recent study, Don Oliver, the Daniel Ayres Professor…

Professor Don Oliver received a three-year grant from the National Institutes of Health (NIH) Academic Research Enhancement Award (AREA) (R15) for his research titled “Mechanism of SecA-dependent protein translocation." The grant, worth $374,148, was awarded on April 15. Oliver is the Daniel Ayres Professor of Biology and professor of molecular biology and biochemistry. Oliver studies how proteins are targeted to and transported across biological membranes utilizing bacteria as a simple model system."The current genetic and biochemical studies are designed to elucidate a molecular motor protein, SecA ATPase, that drives proteins through a universally conserved protein-conducting channel by a largely unknown molecular mechanism,"…

A research group led by Manju Hingorani, associate professor of molecular biology and biochemistry, has published eight papers in 2011-2012 on the mechanisms of DNA replication and repair proteins, independently and in collaboration with research groups at Wesleyan and other national and international universities. The papers are: "Large conformational changes in MutS during DNA scanning, mismatch recognition and repair signaling," published in The EMBO Journal, 2012 (in press). "The Variable Sub-domain of Escherichia coli SecA functions to regulate in the SecA ATPase Activity and ADP release," published in the Journal of Bacteriology, 2012 (March 2 Epub). Don Oliver, the Daniel Ayres Professor of…

Mukerji, Oliver Co-Author Study in PNAS on Basic Cell Function

Oliver Honored with NIH Award for Protein Translocation Research

Hingorani Group Publishes 8 Papers on DNA Mismatch Repair