Science & Technology

Case, Hingorani Coauthor Study on DNA Repair

Molecular biology and biochemistry graduate student Brandon Case and Manju Hingorani, professor of molecular biology and biochemistry, are coauthors on a study published in Nucleic Acids Research in October 2018.

The paper, titled “Coordinated protein and DNA conformational changes govern mismatch repair initiation by MutS,” reports new findings on how the Mutator S (MutS) protein repairs mistakes in the DNA sequence, which is essential for maintaining the accuracy of the genetic code.

The collaborative effort from researchers at Wesleyan, the University of North Carolina at Chapel Hill, and North Carolina State University employed single molecule and ensemble kinetic methods to study the mechanism of action of MutS. The outcome is a unified model of coordinated changes in MutS and DNA conformation that enable the protein to recognize errors in DNA and initiate their repair.

The research at Wesleyan was supported by NIH grant R15 GM114743 awarded to Manju Hingorani.

19th Annual Biophysics Retreat Includes Speakers, Poster Sessions

Wesleyan faculty, students, alumni and guests participated in the 19th annual Molecular Biophysics Retreat Sept. 27 at Wadsworth Mansion.

Wesleyan faculty, students, alumni, and guests attended the 19th annual Molecular Biophysics Retreat Sept. 27 at Wadsworth Mansion. The event included a series of speakers, two poster sessions, and a keynote address.

Alison O’Neil, assistant professor of chemistry, spoke on "Investigating the toxicity of SOD1 aggregates in a stem cell-derived model of ALS." Research in the O'Neil lab is focused on understanding the structure-function relationship of proteins involved in neurodegenerative diseases, specifically ALS.  Utilizing human stem cells allows us to study the unique cell types associated with disease. 

Alison O’Neil, assistant professor of chemistry, spoke on “Investigating the toxicity of SOD1 aggregates in a stem cell-derived model of ALS (amyotrophic lateral sclerosis).” ALS is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Research in the O’Neil lab is focused on understanding the structure-function relationship of proteins involved in neurodegenerative diseases, specifically ALS.

Graduate Students, Faculty Attend Yeast Genetics Meeting

From the left is Anna Rogers and Lorencia Chigweshe, both graduate students in the Molecular biology and Biochemistry program.

Graduate students Anna Rogers and Lorencia Chigweshe presented their poster at the GSA meeting.

Two Wesleyan graduate students and two faculty members presented posters at the GSA Yeast Genetics and Molecular Biology Meeting held at Stanford University on Aug. 22–26. This meeting, which is held once every two years, is organized by the Genetics Society of America (GSA). The meeting brings together hundreds of scientists making groundbreaking discoveries in the field of genetics and gene regulation using the innovative power of yeast genetics.

Both students received a travel grant through Wesleyan’s Melnick Fund to support travel to the conference.

Lorencia Chigweshe presented a poster titled “Interactions between histone variant H2A.Z and linker histone H1 in Saccharomyces cerevisiae meiosis,” while Anna Rogers presented “The histone variant H2A.Z promotes chromosome condensation in Saccharomyces cerevisiae.” Both students are mentored by Scott Holmes, professor of molecular biology and biochemistry, whose lab investigates how the processes of chromosome segregation and gene expression are regulated in eukaryotes.

“We had the opportunity to engage with experts in the field of yeast genetics and learn from them and get insight on our own work,” Chigweshe said. “The conference was a great opportunity to appreciate yeast as a powerful tool for understanding genetics in addition to its industrial application in beer and bread-making.”

Amy MacQueen, associate professor of molecular biology and biochemistry, associate editor for Genetics, cochaired a workshop on scientific publishing and also presented a poster titled “Synapsis and recombination unite at the Zip1’s N-terminal tip” while Mike McAlear, associate professor of molecular biology and biochemistry, presented “Adjacent gene co-regulation (AGC) as a strategy for transcriptional control and coupling.” McAlear is also associate professor, integrative sciences, and Holmes is also professor, integrative sciences.

O’Connell in The Conversation: What Scientists Have Found by Drilling into the Ocean Floor

Suzanne O'Connell

Suzanne O’Connell

Wesleyan faculty frequently publish articles based on their scholarship in The Conversation US, a nonprofit news organization with the tagline, “Academic rigor, journalistic flair. In a new article,Suzanne O’Connell, professor of earth and environmental sciences, writes about the important findings that have resulted from 50 years of scientific drilling on the ocean floor—and how much is still unknown.

Scientists have been drilling into the ocean floor for 50 years – here’s what they’ve found so far

It’s stunning but true that we know more about the surface of the moon than about the Earth’s ocean floor. Much of what we do know has come from scientific ocean drilling – the systematic collection of core samples from the deep seabed. This revolutionary process began 50 years ago, when the drilling vessel Glomar Challenger sailed into the Gulf of Mexico on August 11, 1968 on the first expedition of the federally funded Deep Sea Drilling Project.

I went on my first scientific ocean drilling expedition in 1980, and since then have participated in six more expeditions to locations including the far North Atlantic and Antaractica’s Weddell Sea. In my lab, my students and I work with core samples from these expeditions. Each of these cores, which are cylinders 31 feet long and 3 inches wide, is like a book whose information is waiting to be translated into words. Holding a newly opened core, filled with rocks and sediment from the Earth’s ocean floor, is like opening a rare treasure chest that records the passage of time in Earth’s history.

Gilmore, Greenwood Recipients of NASA Grant to Map Venus’s Craters

Caption: Radar image of Venus. Alpha Regio tessera is partly covered by the dark parabola of the impact crater Stuart on the volcanic plains.

Professors Martha Gilmore and James Greenwood recently received a NASA grant to study crater parabolas on Venus using radar data. Pictured is a Magellan radar image of Venus. Alpha Regio tessera is partly covered by the dark parabola of the impact crater Stuart on the volcanic plains. (Photo courtesy of NASA)

Like planet Earth, the geology of Venus is diverse; consisting of areas of flat plains and deformed, mountain-like terrains called tesserae. And like Earth, Mars, and the Moon, Venus is checkered with hundreds of craters.

“What’s odd about Venus’s craters, is that craters we do see are relatively young, indicating the surface of Venus has been covered by planet-wide volcanic flows,” says Martha “Marty” Gilmore, George I. Seney Professor of Geology, professor of earth and environmental sciences. “The tesserae are the only terrains older than these volcanic flows and thus our only hope at accessing rocks from the first billion years of Venus’s history, when the planet may have had an ocean and may have been habitable.”

As the recipient of a three-year $430,801 grant from NASA’s Solar System Workings Program, Gilmore and James Greenwood, assistant professor of earth and environmental sciences, will use Magellan radar data to create the first map of crater ejecta on Venus classified by origin on plains or tessera terrain. Their project is titled “Radar Emissivity and Dielectric Permittivity of the Venus Surface Beneath Crater Parabolas.” Crater parabolas refer to the shape of the ejecta deposits as they are carried westward by the high-altitude Venus winds.

New Assistant Professor May ’05 Researches Suicide Risk and Prevention

Assistant Professor of Psychology Alexis May

Alexis May ’05

In this issue of The Wesleyan Connection, we speak with Assistant Professor of Psychology Alexis May ’05, who joined the Department of Psychology this fall. May will be among the speakers at the Shasha Seminar for Human Concerns on Sept. 14–15.

Q: Welcome (back) to Wesleyan, Professor May! You earned your BA from Wesleyan in psychology and neuroscience and behavior in 2005. Please tell us about your journey since then.

A: After gaining substantial clinical research experience in the psychology department as a project coordinator for [Walter Crowell University Professor of Social Sciences, Emerita] Ruth Striegel Weismann, I was sure of my passion for clinical science but wasn’t sure how I wanted to pursue that professionally. I took the opportunity presented by this uncertainty to move cross-country to Santa Cruz, Calif., and work some “random” jobs. I landed in a position coordinating a suicide prevention crisis line. I loved the work but was frustrated by how little empirical knowledge there was about suicide prevention. This prompted my decision to return to school to pursue a degree in clinical psychology with a focus on suicide research. I completed my PhD in clinical psychology at the University of British Columbia, my clinical internship at Alpert Medical School of Brown University, and my postdoctoral fellowship at the National Center for Veterans Studies at the University of Utah. Throughout my positions I’ve maintained my focus on understanding the phenomena of suicidal thoughts and behaviors in the service of improving prevention and intervention efforts. Suicide is a devastating, complex, and unsolved problem. I feel very fortunate I get to spend my time working towards better solutions.

Q: How is it being back as a faculty member? Has Wesleyan changed much since your time as a student?

A: I was excited to see how much the psychology department has grown and diversified. I was also thrilled to learn about the addition of the Quantitative Analysis Center—it is a huge resource to both students and faculty. Overall, the students seem as skilled, passionate, and creative as ever!

Sultan, Baker ’18, Berg ’16 Coauthor Paper on Plant Development

Sonia Sultan, professor of biology and professor, environmental studies, and her former students Brennan Baker BA/MA ’18 and Lars Berg ’16 are the coauthors of a paper published in the August 2018 issue of Frontiers in Plant Science.

The study, “Context-Dependent Developmental Effects of Parental Shade Versus Sun Are Mediated by DNA Methylation,” presents work that Baker completed as a BA/MA student in 2017–18. The article is part of a special Frontiers theme on the emerging area of ecological epigenetics.

In this study, the coauthors compared the development of individual plants when their parents were grown in shade or in full sun. The results show that genetically identical seedlings developed very differently just as a result of this difference in parental conditions.

Baker followed up this finding in several ways, including showing that this ‘neo-Lamarckian’ effect on development was conveyed from parents to offspring through epigenetic regulatory changes to DNA expression rather than changes in the genes themselves.

“Learning how environmental effects in the parent generation can influence offspring via these epigenetic mechanisms is one of the most astonishing and important new areas in biology since it challenges the long-held view that only DNA sequence information could be inherited,” Sultan explained.

Baker will be pursuing his work on transgenerational environmental effects in a different biological context. This fall, he is starting an environmental health PhD program at Columbia University, where he plans to study inherited effects of environmental contaminants on human health. Since graduating from Wesleyan, Berg has held a competitive NIH research internship and is planning to go on to medical school.

In addition, a paper by Baker, Sultan, Maya Lopez-Ichikawa ’18, and Robin Waterman ’19 was an invited submission for a special issue of Philosophical Transactions of the Royal Society that is dedicated to adaptive responses to rapid environmental change. The paper is currently under review for publication.

Wesleyan’s Natural History Collection and Curiosities Featured in Usdan

The exhibit "Shelving the History of Life" will be featured inside the display cases in Usdan Universiy Center throughout the fall semester. The true-to-scale exhibit showcases specimens curated, restored, prepared, and documented from the Joe Webb Peoples Museum of Natural History, the former Wesleyan Museum, and other collections on campus.

The exhibit “Shelving the History of Life” will be featured in the display case in Usdan University Center until fall recess. The exhibit showcases specimens curated, restored, and documented from the Joe Webb Peoples Museum of Natural History, the former Wesleyan Museum, and other collections on campus.

In 1870, Orange Judd bequeathed Wesleyan $100,000 to build Judd Hall, which was designed as a building for the study of natural sciences. Included with this building was the Wesleyan Museum, which housed a prominent natural history collection containing over 300,000 specimens.

In 1957, the museum was closed and specimens were donated to other museums, put into storage in various places on campus, or “temporarily” loaned to local schools. In 1970, before the current museum reopened in Exley, the collection stored in the tunnels under Foss Hill was found to have been severely vandalized, with many specimens lost, stolen, or irreparably damaged.

Within the last two years, several Wesleyan faculty, students, and staff have exhumed thousands of these misplaced artifacts and are working to bring them back for public viewing. A new exhibit in Usdan, “Shelving the History of Life,” showcases many of these once-lost, and now found, relics of Wesleyan’s natural history collections.

“This exhibit is a showcase of the spectrum of natural history objects remaining in our collections, including taxidermy specimens, a wide range of wet specimens preserved in alcohol, skeletons, seashells, fossils, and minerals,” explained Andy Tan ’21, who is one of the cocurators of the exhibit.

Robinson in The Conversation: How Gambling Distorts Reality and Hooks Your Brain

Mike Robinson

Mike Robinson

Wesleyan faculty frequently publish articles based on their scholarship in The Conversation US, a nonprofit news organization with the tagline, “Academic rigor, journalistic flair.” In a new article, Mike Robinson, assistant professor of psychology, writes that brain science explains how gambling games hook players, including casual ones. Robinson also is assistant professor of neuroscience and behavior, assistant professor of integrative sciences.

Designed to deceive: How gambling distorts reality and hooks your brain

To call gambling a “game of chance” evokes fun, random luck, and a sense of collective engagement. These playful connotations may be part of why almost 80 percent of American adults gamble at some point in their lifetime. When I ask my psychology students why they think people gamble, the most frequent suggestions are for pleasure, money, or the thrill.

While these might be reasons why people gamble initially, psychologists don’t definitely know why, for some, gambling stops being an enjoyable diversion and becomes compulsive. What keeps people playing even when it stops being fun? Why stick with games people know are designed for them to lose? Are some people just more unlucky than the rest of us, or simply worse at calculating the odds?

As an addiction researcher for the past 15 years, I look to the brain to understand the hooks that make gambling so compelling. I’ve found that many are intentionally hidden in how the games are designed. And these hooks work on casual casino-goers just as well as they do on problem gamblers.

Students Share Summer Research Projects at Poster Session

Cher Qin ’21 presented her quantitative analysis study titled “Text Classification of 2016 Presidential Campaign Advertisement” during a poster session July 26. Qin’s advisors are Pavel Oleinikov, associate director of the Quantitative Analysis Center, and Erika Franklin Fowler, associate professor of government.

More than 135 undergraduate research fellows shared their summer-long research during a poster session on July 26 in Exley Science Center.

Students from the Psychology Department, College of the Environment, Biology Department, Neuroscience and Behavior Program, Chemistry Department, Physics Department, Astronomy Department, Math and Computer Science Department, Quantitative Analysis Center, Molecular Biology and Biochemistry Department, and Astronomy Department presented posters. Posters often contain text, graphics, and images that illustrate the students’ research results on a single board. Poster session attendees can view the posters and interact with the authors.

The summer research program is hosted by the College of Integrative Sciences.

“We had possibly the largest poster session ever this year, with presentations by students from across the sciences, as well as many departments in the social sciences,” said Francis Starr, professor of physics, professor of integrative sciences, professor of molecular biology and biochemistry, head of the College of Integrative Sciences. “Year after year, I am in awe of what our Wesleyan students are capable of.”

Photos of the poster sessions are below: (Photos by Olivia Drake)

Rochelle Spencer ’20 shared her poster titled “Dendrimer Synthesis via Highly Efficient Thoil-Michael Reactions.” Her advisor is Brian Northrop, associate professor of chemistry, associate professor of integrative sciences.

Personick Honored with Young Investigator Program Award from Army Research Office

Michelle Personick joined the faculty this fall, and is teaching courses in Chemistry of Materials and Nanomaterials and an Integrated Chemistry Lab. (Photo by Olivia Drake)

Michelle Personick

Michelle Personick, assistant professor of chemistry, is the recipient of a three-year, $339,000 Young Investigator Program grant funded by the U.S. Army Research Office. Personick will use the funds to support her nanoparticle research, which ultimately may protect military soldiers from hazardous chemicals and materials.

The Army’s Young Investigator Program is designed to identify and support talented scientists and engineers who show exceptional promise for doing creative research, in order to encourage their teaching and research careers. The program is open to U.S. citizens, Nationals, and resident aliens holding tenure-track positions at U.S. universities and colleges, who have held their graduate degrees for fewer than five years at the time of application.