A paper co-authored by Rich Olson, associate professor of molecular biology and biochemistry, and Sophia Levan ’12 was published in The Journal of Molecular Biology, March 2013. The article is titled, “Vibrio cholerae Cytolysin Recognizes the Heptasaccharide Core of Complex N-Glycans with Nanomolar Affinity.”
The human intestinal pathogen Vibrio cholerae secretes a pore-forming toxin, V.cholerae cytolysin (VCC), which contains two domains that are structurally similar to known carbohydrate-binding proteins. Olson and Levan used a combination of structural and functional approaches to characterize the carbohydrate-binding activity of the VCC toxin.
At Wesleyan, Levan was the recipient of the Butterfield Prize, the Graham Prize and she was a member of Phi Beta Kappa. She’s currently a student at Harvard University.