For the roughly one-third of temporal lobe epilepsy patients for whom drugs are not an option, researchers at Wesleyan are paving the way for alternative therapies using stem cells.
Faculty members Janice Naegele, Gloster Aaron and Laura Grabel, together with Xu Maisano, Ph.D. ’11, Elizabeth Litvina, B.A. ’10/M.A. ’11, and Stephanie Tagliatela, the lab manager in the Naegele lab, recently published a landmark study in the Journal of Neuroscience on the use of embryonic stem cells to treat temporal lobe epilepsy (TLE). The researchers derived neural “parent cells” in culture from mouse embryonic stem cells, and transplanted them into the brains of epileptic mice. There, the transplanted cells differentiated into mature inhibitory neurons and successfully integrated and formed connections in the host brain over the course of several months.
The paper, published Jan. 4, is available to read online.
“In these experiments, we are attempting to repair an important region called the dentate gyrus, located deep inside the temporal lobe in the hippocampus. The structures affected in temporal lobe epilepsy are important for forming memories and controlling the spread of seizures throughout the brain. When inhibitory neurons in the hippocampus are injured or die off, seizures are able to spread into other brain regions, causing more severe seizures,” explains Naegele, professor of biology, professor of neuroscience and behavior.