Gloster Aaron, assistant professor of biology, assistant professor of neuroscience and behavior, received a $50,000 grant from The Epilepsy Foundation on Dec. 6 titled “STEP Regulation of Epileptogensis in the Hippocampus.”
Drugs prescribed to combat epilepsy can yield unwanted side effects. One reason that drugs have side effects is that they can affect almost every neuron in the brain, regardless of their roles in spreading seizures. Aaron will research ways target only the neurons that may be most important in stopping the spread of seizures. Previous work has shown that a certain protein, STEP, is found in select groups of neurons. One of those groups of neurons, the hilar interneurons of the hippocampus, is a crticial group with regards to epilepsy. By manipulating that protein, researchers can target that group of neurons, and hopefully gain traction in a selective therapy for preventing and curing epilepsy.