Philip Bolton, professor of chemistry; Dobroslawa Bialonska, postdoctoral fellow in in chemistry; and chemistry graduate student Kenneth Song are the co-authors of “Complexes of mismatched and complementary DNA with minor groove binders. Structures at nucleotide resolution via an improved hydroxyl radical cleavage methodology,” published in Mutation Research, 726(1): pages 47-53, 2011.
In this paper, the authors explain how they’ve developed a protocol to investigate the structures of the complexes of damaged DNA with drug like molecules. Tumor cell lines can replicate faster than normal cells and many also have defective DNA repair pathways. This has lead to the investigation of the inhibition of DNA repair proteins as a means of therapeutic intervention. An alternative approach is to hide or mask damaged DNA from the repair systems. The full abstract is online here.
Paul Karl Haake, professor of molecular biology and biochemistry, emeritus, died on Dec. 3 in Middletown, Conn. He was 79 years old. A memorial service was held Dec. 7 at the Wasch Center for Retired Faculty.
In the true spirit of the liberal arts and the Wesleyan tradition of service, Professor Haake was particularly proud of the popularcourses he taught to students outside the sciences and of his participation in community issues. In 1975, Governor Grasso appointed Professor Haake to the Connecticut’s Nuclear Power Evaluation Council, a commission concerned with the safety of nuclear power.
Professor Haake completed his A.B. (1954) and Ph.D. (Chemistry, 1961) at Harvard University. His doctoral research on hydrolysis and isotopic exchange, under the supervision of Frank Westheimer, resulted in the 1961 publication of his paper “Hydrolysis and Exchange in Esters of Phosphoric Acid,” published in the Journal of the American Chemical Society. After initially beginning his teaching career at UCLA, where he taught from 1961-68, Haake joined the Wesleyan faculty in 1968.
During his 25 years as a full-time teacher and scholar at Wesleyan, Haake contributed to the development of the Ph.D. program in chemistry and the formulation of the Molecular Biology and Biochemistry Department. He also initiated the NSM luncheon series, an important interdisciplinary forum for Division III, and played a vital role in strengthening general education offerings across the Division III. His research resulted in publication of some one hundred scholarly articles and books. In 2004, after a dozen years in whichProfessor Haake split his time between teaching at Wesleyan and various other pursuits, he fully retired from Wesleyan.
(Information provided by Rob Rosenthal, provost and vice president of Academic Affairs, the John E. Andrus Professor of Sociology.)
Erika Taylor, assistant professor of chemistry, assistant professor of environmental studies, is the co-author of “Lipopolysaccharide Biosynthesis without the Lipids: Recognition Promiscuity of Escherichia coli, Heptosyltransferase I,” published by the American Chemical Society in Nov. 2011. The abstract is available here.
Stewart Novick, professor of chemistry, received a grant worth $43,260 from the National Science Foundation. The award is shared with Professor Stephen Cooke of SUNY-Purchase and represents a new collaboration between Professors Cooke and Novick who now co-mentor graduate students and share sophisticated equipment (Fourier transform microwave spectrometers housed in Novick’s lab at Wesleyan). The collaboration, which goes beyond this one grant, involves investigating the structures and dynamics of a whole range of systems including large halogenated compounds and molecules involving actinide valence electrons in their chemical bonding.
Manju Hingorani, associate professor of molecular biology and biochemistry, co-authored a study titled “hMSH2 controls ATP processing by hMSH2-hMSH6,” published in the Journal of Biological Chemistry on Sept. 19. The abstract is online here.
Hingorani co-authored another study with David Beveridge, the Joshua Boger University Professor of the Sciences and Mathematics, professor of chemistry, titled “Allosterism in Muts Proteins: How DNA Mismatch Recognition Signals Repair.” The study was published in the Biophysical Journal in 2011. The abstract is online here.
Brian Northrop, assistant professor of chemistry, has published “Substituent Effects on the Reversibility of Furan-Maleimide Cycloadditions” in the Journal of Organic Chemistry. His co-author is Robert Boutelle, a 2011 Wesleyan graduate who is now a graduate student at UCLA. The paper is online here.
Philip Bolton, professor of chemistry, has published “Complexes of mismatched and complementary DNA with minor groove binders: Structures at nucleotide resolution via an improved hydroxyl radical cleavage methodology” in Mutation Research, 2011. The article is online here.
Becky Lee '10 and Professor David Beveridge at the Institute of Technology in New Delhi, India.
David Beveridge, the Joshua Boger University Professor of Natural Sciences and Mathematics, professor of chemistry, was on sabbatical last spring at the Indian Institute of Technology (IIT) in New Delhi, India. He was visiting and working on research projects with Professor B. Jayaram, director of the Supercomputer Center for Bioinformatics, SCFBIO.
Beveridge’s former student, Becky Lee ’10, was spending a year doing research in Jayaram’s SCFBIO research group on a project in computational biophysics.
Beveridge presented one of the thematic lectures on “Dynamic Allosterism” in a lecture series celebrating the 50th anniversary of IIT-Delhi.
David Beveridge, the Joshua Boger University Professor of the Sciences and Mathematics, professor of chemistry, received a five year graduate student training grant from the National Institutes of Heath (NIH) in support of Wesleyan’s interdepartmental program in Molecular Biophysics and Biological Chemistry (MBBC). This program is co-coordinated by Ishita Mukerji, professor of molecular biology and biochemistry, director of graduate studies.
The MBBC Program involves 12 faculty members from chemistry, biology, MB&B and physics departments along with both graduate Ph.D. students and undergraduate certificate students. The grant, worth $662,820, is the latest in a series of awards to this program, which has been supported by the NIH since 1988.
Hughes Fellow Patrick Sarver '14 is spending his summer working with Michael Calter, associate professor of chemistry. He studies “The Catalytic, Asymmetric ‘Interrupted’ Feist-Benary Reaction."
Through a grant from the Howard Hughes Medical Institute, the Wesleyan Hughes Summer Research Program supports undergraduate education in the life sciences. This summer, Wesleyan is hosting 43 Hughes Fellows and approximately 65 Hughes Associates. Hughes Associates are not funded by Hughes, but they participate in Hughes activities.
The program runs from May 25 to July 29 and is open to freshmen, sophomores and juniors currently enrolled at Wesleyan. Fellows receive a $4,000 stipend and are expected to work full-time on their research.
Wesleyan faculty members serve as mentors in the Hughes Summer Research Program. The Summer Program also includes weekly seminars and workshops, a symposium, various social events, and a closing Poster Session. More information on the Wesleyan Hughes Program is online here.
Below is a video and several photographs of 2011 Summer Hughes Fellows:
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