Hingorani, Biro ’09 Co-Author Article on Metal Toxin

Manju Hingorani, associate professor of molecular biology and biochemistry, is the co-author of “Mechanism of Cadmium-mediated Inhibition of Msh2-Msh6 Function in DNA Mismatch Repair,” published in Biochemistry, March 25, 2009. Three undergraduates from three countries worked on the project in the Hingorani Lab at Wesleyan. They include Francis Noah Biro ’09; Markus Wieland, an exchange student from University of Konstanz; and Karan Hingorani, Manju Hingorani’s nephew from St. Xaviers College in Mumbai who did volunteer work in the lab. The project focused on how the heavy metal toxin Cadmium (found in cigarette smoke, industrial pollution, batteries, etc.) causes DNA damage and blocks DNA repair, which promotes development of cancer.

Hingorani also co-authored the article “Mechanism of ATP-Driven PCNA Clamp Loading by S. cerevisiae RFC,” published in the Journal of Molecular Biology, March 13, 2009.