Tag Archive for faculty publications

Thayer, Galganov ’17, Stein ’17 Publish Article on Allosteric Signaling

A new article by Visiting Assistant Professor in Computer Science Kelly Thayer and students in her Spring 2017 Scientific Computing class is challenging conventional metrics used in allosteric signaling—the regulation of an enzyme by a binding molecule at a site other than the enzyme’s active site.

“What’s special about allostery is that a molecule called an allosteric effector binds at one location, and the change happens somewhere else,” Thayer explained. “What we were trying to understand was: How does that signal get across?”

Paige’s Short Stories Published in Literary Magazines

Paula Paige, adjunct professor of romance languages and literatures, emerita, is the author of five short stories published in literary magazines in 2016-18. These include:

Flu Story” published in Newfound, Vol, 8, Issue 2, 2018. 

Daddy,” published in The Umbrella Factory, Issue 29, September 2017.

“Roman Ruins:  an Update on a Once Great Beauty,” published in Artes Magazine, May 26, 2017.

The Baby Sitter,” published by the Diverse Arts Project, August 2016.

Gluten and Other Abominations,” published by Sundress Publications, June 2016.

Paula Paige taught at Wesleyan for 30 years. She is the recipient of the 2010 Our Stories Gordon Award for her flash fiction piece “Mosiach is Here.” Most recently, she was shortlisted for Glimmer Train’s February 2014 Short Story Award for New Writers, and First Runner-up in Red Hen Press’s 2015 Short Story Award. Paige also has translated two 19th century Italian literary fiction pieces with Northwestern University Press.

E&ES Faculty, Alumni Author Article on New Method for Saharan Dust Collection in the Caribbean

Earth and Environmental Sciences faculty and senior seminar students have identified a potentially fast and inexpensive method for collecting and measuring Saharan dust in the Caribbean.

E&ES faculty members Dana Royer, Tim Ku, Suzanne O’Connell, and Phil Resor, and students Kylen Moynihan ’17, Carolyn Ariori ’09, Gavin Bodkin ’09, Gabriela Doria MA’09, Katherine Enright ’15, Rémy Hatfield-Gardner ’17, Emma Kravet ’09, C. Miller Nuttle ’09, and Lisa Shepard ’17 have coauthored an article published in the January 2018 issue of Atmospheric Environment. The paper, titled “Tank Bromeliads capture Saharan dust in El Yunque National Forest, Puerto Rico,” summarizes student research performed in three senior seminar capstone projects conducted over an eight-year period starting in January 2009.

Saharan Africa produces approximately 800 billion kilograms of dust each year, a significant portion of which is carried via wind across the Atlantic Ocean to the Caribbean. These dust particles provide critical components for Caribbean ecosystems, including viable fungi and bacteria, but current methods for measuring the dust can be either expensive or limited in the amount and purity of samples collected.

Royer and his team sought to test whether Saharan dust could be detected within the bromeliad tanks of the El Yunque National Forest in Puerto Rico, and “to test how well tank bromeliads serve as a natural vessel for distinguishing the regional sources of atmospheric deposition.”

The team theorized that the overlapping structure of the bromeliad’s leaves, which is used to capture rainwater and nutrient-rich debris, could provide a feasible way to measure and trace Saharan dust in the Caribbean. Over the course of three field campaigns, the team sampled the bromeliad tanks, soil, and bedrock at three different sites in the El Yunque dwarf forest. Their findings confirmed that the contents of the tested tanks could be analyzed to identify the source of atmospheric dust inputs, thus providing a potentially simpler and lower-cost alternative to existing methods of collection and measurement.

Elphick Edits Late Professor’s Book on the History of South Africa’s Racial Segregation

Book by Jeffrey Butler

Book by Jeffrey Butler

The late Jeffrey Butler, professor of history, emeritus, is the author of Cradock: How Segregation and Apartheid came to a South African Town, published by the University of Virginia Press, December 2017. Richard “Rick” Elphick, professor of history, emeritus, co-edited the book with the late Jeannette Hopkins, a former director of Wesleyan University Press.

According to the book’s abstract, Cradock, the product of more than 20 years of research by Butler, is a vivid history of a middle-sized South African town in the years when segregation gradually emerged, preceding the rapid and rigorous implementation of apartheid. Although Butler was born and raised in Cradock, he avoids sentimentality and offers an ambitious treatment of the racial themes that dominate recent South African history through the details of one emblematic community. Augmenting the obvious political narrative, Cradock examines poor infrastructural conditions that typify a grossly unequal system of racial segregation but otherwise neglected in the region’s historiography. Butler shows, with the richness that only a local study could provide, how the lives of blacks, whites, and mixed-race individuals were affected by the bitter transition from segregation before 1948 to apartheid thereafter.

BIOL310 Students Collaborate on Scientific Journal Article

Twenty-three students and one faculty member are co-authors of a forthcoming manuscript in G3.

Twenty-three students and one faculty member are co-authors of a forthcoming manuscript in the journal G3.

More than 20 Wesleyan students — including three former first-years — are co-authors of a research manuscript accepted for publication in a prestigious biology research journal. The paper focuses on a species of fruit fly that has evolved, and has the ability to ingest a toxic plant.

The paper, which is forthcoming in G3: Genes | Genomes | Genetics, is the result of a study completed by BIOL310 Genomics Analysis students. Course instructor and co-author Joseph Coolon, assistant professor of biology, created BIOL310 to provide students a course-based research experience focused on measuring gene expression.

“Because the students in the course and in my lab collaborated on all the analysis, interpretation, and wrote the paper, all 23 students are co-authors of the published manuscript,” Coolon said. “G3 is a well-known and highly reputable journal for publishing in my field and I am honored to have been able to publish there, especially given the number of undergraduates that are now published authors in such a great journal.”

Volcanoes Caused Ecological Disruption Says Thomas in Nature Article

Ellen Thomas

Ellen Thomas, University Professor in the College of Integrative Sciences and research professor of earth and environmental sciences, is a co-author of a paper titled “Very Large Release of Mostly Volcanic Carbon During the Paleocene-Eocene Thermal Maximum,” published in the weekly science journal Nature on Aug. 31.

The study focused on Palaeocene–Eocene Thermal Maximum, a surface warming event associated with ecological disruption that occurred about 56 million years ago, releasing a large amount of carbon. The researchers combined boron and carbon isotope data in an Earth system model and found that the source of carbon was much larger than previously thought.

Most of the carbon, Thomas and her colleagues discovered, was probably released by volcanism during the opening of the North Atlantic Ocean when Greenland separated from Europe.

The paper also was cited in another Nature article, on PhysOrg and on Science Daily.

Knee Co-Authors Article on Hydrogen-Bonding Interactions

Joseph Knee, the Beach Professor of Chemistry and Dean of the Natural Sciences and Mathematics Division, is the author of a new article published in the journal Physical Chemistry Chemical Physics (PCCP). This “Perspectives” article, which was commissioned by the PCCP editorial board and editorial office, is a high-profile look at work by Knee and his collaborators that has been going on for nearly a decade. Perspectives articles are intended to present an authoritative state-of-the-art account of a particular research field.

The research by Knee and his collaborators, which is ongoing, uses experimental and computational methods to explore hydrogen bonding interactions, which are extremely important in the structure of water, various solutions, and in many key biochemical structures and processes.

Knee explains, “The most important aspect of our methodology is making careful experimental measurements of two single molecules forming hydrogen bonds and then modeling these bonds with modern quantum chemical calculations. The calculations allow us to decompose the various forces which contribute to the bond strength and structure. The larger goal is to generalizing this insight to more complex hydrogen bonded systems, particularly hydrogen bonding networks which exist in liquids and biological systems.”

The full article can be read here by those with subscriptions or institutional subscriptions, including those on Wesleyan’s campus.

Niraula MA ’18, Redfield Lead Team in Discovery of 3 Super-Earths

A team of scientists from Wesleyan, led by Associate Professor of Astronomy Seth Redfield and graduate student Prajwal Niraula MA’18, discovered three super-Earths transiting around a nearby star, just 98 light-years from Earth. This NASA-generated image was created to depict 55 Cancri e, a super-Earth 40 light-years away from Earth.

A team of scientists from Wesleyan discovered three super-Earths transiting around a nearby star, 98 light-years away. The NASA-generated image above depicts a different super-Earth: 55 Cancri e, discovered in 2004.

A team of scientists from Wesleyan, led by Associate Professor of Astronomy Seth Redfield and graduate student Prajwal Niraula MA ’18, has co-authored a paper on the discovery of three planets, or super-Earths, transiting around a nearby star, just 98 light-years away.

“Super-Earths are slightly larger than Earth, and the three of them straddle the divide between the rocky planets like Earth and ice giants like Neptune,” explains Redfield.

These planets were found using the Kepler Space Telescope. “Kepler has found thousands of exoplanets these last eight years, but this is the closest planetary system that Kepler has ever found, although closer planetary systems have been found using different telescopes,” says Redfield.

Hingorani, Lui, Zhou PhD ’13 Published in Biological Chemistry Journal

Three scholars from the Molecular Biology and Biochemistry Department are co-authors of a study published in The Journal of Biological Chemistry in August 2017. The paper is titled “Linchpin DNA-binding residues serve as go/no-go controls in the replication factor C-catalyzed clamp loading mechanism.”

The co-authors, Manju Hingorani, chair and professor of molecular biology and biochemistry, professor of integrative sciences; Juan Liu, research associate; and Zayan Zhou, PhD ’13, performed the study on Replication Factor C (RFC) and proliferating cell nuclear antigen (PCNA), which are two essential proteins required for DNA replication and repair in all living organisms.

The researchers found new mechanistic information about how different parts of the RFC protein work together to load PCNA onto DNA (by “clamp loading”), which allows PCNA to help dozens of other proteins to replicate and repair DNA.

The Hingorani group investigates proteins responsible for DNA replication and repair. These proteins maintain genome and cell integrity, and their malfunction leads to cancer and other diseases.

Kleinberg’s Book Argues for a Deconstructive Approach to the Practice, Writing of History

Ethan Kleinberg, director of the Center for the Humanities, is the author of Haunting History: For a Deconstructive Approach to the Past, published by Stanford University Press in August 2017.

“Haunting History is about the ways we think about the past and ‘do’ history at a moment when the digital revolution is changing how we conduct research, store materials, and even write,” Kleinberg said. “In it I argue that many of strategies for writing about, but also understanding the past, are conditioned by the analog practices of the previous century which has served to create the illusion that the past can be studied like an object held in your hand or placed under a microscope.”

The past — by definition — is gone and thus has no definite properties or perhaps we can say that is has latent properties that are activated when we do history, Kleinberg explained. “But this activation of the past is always partial leaving remains that are hidden or dormant. This is a past that is absent but haunts us and can return in ways that disturb our conventional historical narratives and understanding of what the past and history is.”

To account for this play of absence and presence, Kleinberg advocate for a “hauntological” approach to the past.

Bloom ’75, Sawhney Explore the Elm City’s Underbelly in New Haven Noir

New Haven Noir, edited by Amy BloomA star-studded cast of contributors curated by Shapiro-Silverberg Professor of Creative Writing Amy Bloom ’75 fill the pages of New Haven Noir, featuring original stories from Michael Cunningham, Stephen Carter, Roxana Robinson, Assistant Professor of English Hirsh Sawhney and many others. The book is the latest addition to an award-winning series of original noir anthologies published by Akashic Books, founded by publisher and editor-in-chief Johnny Temple ’88.

“I’m a big fan of noir,” says Bloom, editor of the anthology, which has garnered praise from both Publishers Weekly and Kirkus Reviews. “When Johnny called me and said, I don’t know if you’re from New Haven, but I know you’re connected to New Haven and I’d love you to edit the anthology, I jumped at the opportunity,” she said.

Bloom worked with Temple to select contributors for the anthology, with Bloom choosing to invite several writer friends who hadn’t written noir before, including Alice Mattison and Michael Cunningham. “I told them, it’s conflict and it’s mystery. Bleak. Snappy outfits. Great dialogue,” Bloom said. “And they said, count us in.”

In addition to serving as editor of the anthology, Bloom also is a contributor. Her story, “I’ve Never Been to Paris,” set in New Haven’s East Rock neighborhood, is actually an excerpt from a mystery she wrote years ago, tailored specifically for New Haven Noir.

Sawhney Authors E-Book on Race, Police Brutality

Hirsh Sawhney, assistant professor of English, is the author of a recent work of fiction titled The Diary of Rehan Malhotra, published as an e-book by Juggernaut Books (2017).

In this timely story, Rehan, the son of a Muslim mother and Hindu father, is a middle-aged high school teacher in New Haven, Conn., who struggles with his growing estrangement from his wife and the affluent, white community in which he lives. A charged encounter with a neighbor causes him to look back on his troubled teenage years, when he used and sold drugs, and when he forged a problematic friendship with a young black man named Ink. The Diary of Rehan Malhotra casts a spotlight on the invisible walls that divide city from suburb, which keep some people safe and others confined. It is a meditation on the possibilities and limitations of literature as a cure for social ills.

The story costs 10 rupees, or 15 cents, and is being published as a part of Juggernaut’s efforts to get inexpensive, quality literature to as diverse a readership as possible.

Sawhney is also the author of South Haven and the editor of Delhi Noir. He also collaborated with Amy Bloom ’75 on New Haven Noir, Hirsh has lived in Delhi, London and New York City.