Olivia DrakeManju Hingorani, professor of molecular biology and biochemistry, is the author of "Distinct structural alterations in proliferating cell nuclear antigen block DNA mismatch repair," published in Biochemistry on Aug. 20, 2013. Read an abstract of the paper online here. She's also the author of "Slow Conformational Changes in MutS and DNA Direct Ordered Transitions between Mismatch Search, Recognition and Signaling of DNA Repair," published in The Journal of Molecular Biology on Aug. 20, 2013. Her former students, F. Noah Biro '09 and Christopher Doucette '11 co-authored the paper. Read the abstract online here.
Two faculty members and two graduate students co-authored a paper published in the July 18 edition of the academic journal, Biochemistry. Erika Taylor, assistant professor of chemistry, assistant professor of environmental studies; Manju Hingorani, professor of molecular biology and biochemistry; chemistry graduate student Daniel Czyzyk; and molecular biology and biochemistry graduate student Shreya Sawant wrote the paper, "Escherichia coli Heptosyltransferase I: Investigation of Protein Dynamics of a GT-B Structural Enzyme." It appears online here. Biochemistry is a publication of the American Chemical Society.
A research group led by Manju Hingorani, associate professor of molecular biology and biochemistry, has published eight papers in 2011-2012 on the mechanisms of DNA replication and repair proteins, independently and in collaboration with research groups at Wesleyan and other national and international universities. The papers are: "Large conformational changes in MutS during DNA scanning, mismatch recognition and repair signaling," published in The EMBO Journal, 2012 (in press). "The Variable Sub-domain of Escherichia coli SecA functions to regulate in the SecA ATPase Activity and ADP release," published in the Journal of Bacteriology, 2012 (March 2 Epub). Don Oliver, the Daniel Ayres Professor of…
Manju Hingorani, associate professor of molecular biology and biochemistry, co-authored a study titled "hMSH2 controls ATP processing by hMSH2-hMSH6," published in the Journal of Biological Chemistry on Sept. 19. The abstract is online here. Hingorani co-authored another study with David Beveridge, the Joshua Boger University Professor of the Sciences and Mathematics, professor of chemistry, titled "Allosterism in Muts Proteins: How DNA Mismatch Recognition Signals Repair." The study was published in the Biophysical Journal in 2011. The abstract is online here.
Manju Hingorani, associate professor of molecular biology and biochemistry, received a $165,038 grant from the Connecticut Department of Health to support her project titled “DNA Mismatch Repair in Tobacco Smoke Medicated Cancer.” The project will be funded for 18 months.
A Connecticut Department of Public Health (DPH) award will fund a biomedical research project on tobacco-related illnesses. On Oct. 26, Senator Joseph Crisco (D-Woodbridge) presented Manju Hingorani, associate professor of molecular biology and biochemistry, with one of the eight awards, supported by the Connecticut DPH Biomedical Trust Fund. Hingorani received a $165,083 grant to promote understanding of the mechanisms whereby DNA mismatch repair suppresses carcinogenesis and development of refractory cancers. "While we have made considerable progress in the area of tobacco use prevention, tobacco-related illnesses continue to be the leading causes of disability and death," said Senator Crisco, sponsor of…
Manju Hingorani, associate professor of molecular biology and biochemistry, received a $165,083 grant from the Connecticut Department of Health for her study titled “Role of DNA Mismatch Repair in Tobacco Smoke-Mediated Carcinogenesis.” The grant will fund a post-doc and research associate’s projects through September 2012. Also, Hingorani, received a $497,532 grant from the National Institutes of Health for her study titled “PCNA Clamp Mechanisms in DNA Replication and Repair.” The grant will fund graduate and undergraduate students’ research projects through June 2013. The project is supported by Award number R15GM094047 from the National Institute of General Medical Sciences. Also, Hingorani…
Manju Hingorani, associate professor of molecular biology and biochemistry, is the author of "S. cerevisiae Msh2-Msh6 DNA binding kinetics reveal a mechanism of targeting sites for DNA mismatch repair," published in the Proceedings of the National Academy of Sciences " Early Edition," December 2009. Dana Royer, assistant professor of earth and environmental sciences, is the author of "Fossil soils constrain ancient climate sensitivity," published in the same journal.
Manju Hingorani, associate professor of molecular biology and biochemistry, is the co-author of "Mechanism of Cadmium-mediated Inhibition of Msh2-Msh6 Function in DNA Mismatch Repair," published in Biochemistry, March 25, 2009. Three undergraduates from three countries worked on the project in the Hingorani Lab at Wesleyan. They include Francis Noah Biro '09; Markus Wieland, an exchange student from University of Konstanz; and Karan Hingorani, Manju Hingorani's nephew from St. Xaviers College in Mumbai who did volunteer work in the lab. The project focused on how the heavy metal toxin Cadmium (found in cigarette smoke, industrial pollution, batteries, etc.) causes DNA damage…