Olivia DrakeIn August, Michael McAlear, chair and associate professor of molecular biology and biochemistry, presented an interactive lecture about Africa’s water cycle to the Kibera School for Girls. Kennedy Odede '12 and Jessica Posner '09 operate the school and the non-profit organization Shining Hope for Communities in Kibera, Kenya. McAlear’s lecture included an experiment with test tubes he brought for the school. His sons, Matthew and Thomas, donated time in the school’s library. “We cannot thank Professor McAlear and his sons enough for their generous donation of supplies, time, and energy,” Posner says in her blog.
Robert Lane, associate professor of molecular biology and biochemistry, received a grant worth $1,796,029 from the National Institutes of Health to support his research on “Mutually Exclusive Odorant Receptor Regulation. The grant supports the study through April 30, 2015.
For the next three years, the National Science Foundation (NSF) will support gene expression research led by Scott Holmes, associate professor of molecular biology and biochemistry. On March 2, the NSF awarded Holmes a $599,832, three-year grant for his studies on "Epigenetic Silencing of Gene Expression in Saccharomyces cerevisiae." Gene expression refers to the observable characteristics generated on a molecular level by a particular sequence of DNA or gene; epigenetic controls are essential in maintaining the specific patterns of gene expression that distinguish hundreds of distinct cell types in skin, muscles and other types of tissue. "I’m thrilled to get…
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Manju Hingorani, associate professor of molecular biology and biochemistry, is the author of "S. cerevisiae Msh2-Msh6 DNA binding kinetics reveal a mechanism of targeting sites for DNA mismatch repair," published in the Proceedings of the National Academy of Sciences " Early Edition," December 2009. Dana Royer, assistant professor of earth and environmental sciences, is the author of "Fossil soils constrain ancient climate sensitivity," published in the same journal.
Baltimore native Esther McCready grew up in segregated, discriminatory world and was denied admission to the University of Maryland School of Nursing. At that time, the school did not admit "Negros." With help from NAACP civil rights leaders like Thurgood Marshall, she sued for admission to the university, and in April 1950, McCready won her right to attend classes. In the spring semester course "Making the Science Documentary," molecular biology and biochemistry major Christopher Doucette '11 had the opportunity to interview and film McCready about being the first African American woman to attend Maryland's School of Nursing. He also interviewed…
Manju Hingorani, associate professor of molecular biology and biochemistry, is the co-author of "Mechanism of Cadmium-mediated Inhibition of Msh2-Msh6 Function in DNA Mismatch Repair," published in Biochemistry, March 25, 2009. Three undergraduates from three countries worked on the project in the Hingorani Lab at Wesleyan. They include Francis Noah Biro '09; Markus Wieland, an exchange student from University of Konstanz; and Karan Hingorani, Manju Hingorani's nephew from St. Xaviers College in Mumbai who did volunteer work in the lab. The project focused on how the heavy metal toxin Cadmium (found in cigarette smoke, industrial pollution, batteries, etc.) causes DNA damage…
Errors in genomic DNA can lead to tumors and other diseases. By probing specific DNA structures, Ishita Mukerji hopes to gain an understanding of how such medical conditions can be prevented or possibly cured. Mukerji, professor of molecular biology and biochemistry, studies how different proteins recognize and bind to DNA. Specifically, she examines four-stranded DNA structures, known as "Holliday junctions," which are involved in DNA repair and recombination. These are different from the common, two-stranded DNA. On April 1, Mukerji will receive a four-year grant worth $798,368 from the National Science Foundation (NSF) to fund her research project, "Structure and…
During a "Who Done It? A DNA Investigation," elementary school aged children sported white lab coats and became "detectives" hoping to solve a crime. The students learned about DNA structure by isolating DNA from wheat germ and comparing DNA samples from a 'crime scene' with the DNA from five suspects. They learn how DNA forensics actually works – just like on the television show "CSI." (more…)