Olivia DrakeBaltimore native Esther McCready grew up in segregated, discriminatory world and was denied admission to the University of Maryland School of Nursing. At that time, the school did not admit "Negros." With help from NAACP civil rights leaders like Thurgood Marshall, she sued for admission to the university, and in April 1950, McCready won her right to attend classes. In the spring semester course "Making the Science Documentary," molecular biology and biochemistry major Christopher Doucette '11 had the opportunity to interview and film McCready about being the first African American woman to attend Maryland's School of Nursing. He also interviewed…
Manju Hingorani, associate professor of molecular biology and biochemistry, is the co-author of "Mechanism of Cadmium-mediated Inhibition of Msh2-Msh6 Function in DNA Mismatch Repair," published in Biochemistry, March 25, 2009. Three undergraduates from three countries worked on the project in the Hingorani Lab at Wesleyan. They include Francis Noah Biro '09; Markus Wieland, an exchange student from University of Konstanz; and Karan Hingorani, Manju Hingorani's nephew from St. Xaviers College in Mumbai who did volunteer work in the lab. The project focused on how the heavy metal toxin Cadmium (found in cigarette smoke, industrial pollution, batteries, etc.) causes DNA damage…
Errors in genomic DNA can lead to tumors and other diseases. By probing specific DNA structures, Ishita Mukerji hopes to gain an understanding of how such medical conditions can be prevented or possibly cured. Mukerji, professor of molecular biology and biochemistry, studies how different proteins recognize and bind to DNA. Specifically, she examines four-stranded DNA structures, known as "Holliday junctions," which are involved in DNA repair and recombination. These are different from the common, two-stranded DNA. On April 1, Mukerji will receive a four-year grant worth $798,368 from the National Science Foundation (NSF) to fund her research project, "Structure and…
During a "Who Done It? A DNA Investigation," elementary school aged children sported white lab coats and became "detectives" hoping to solve a crime. The students learned about DNA structure by isolating DNA from wheat germ and comparing DNA samples from a 'crime scene' with the DNA from five suspects. They learn how DNA forensics actually works – just like on the television show "CSI." (more…)
A group of Wesleyan faculty, graduate and undergraduate students, along with three post-docs from the Molecular Biology and Biochemistry and Chemistry departments, attended the 53rd Annual Biophysical Society Meeting in Boston. Several labs contributed posters including those run by David Beveridge, the University Professor of the Sciences and Mathematics, professor of chemistry; Irina Russu, professor of chemistry; Manju Hingorani, associate professor of molecular biology and biochemistry; Don Oliver, the Daniel Ayres Professor of Biology, chair and professor of molecular biology and biochemistry; and Ishita Mukerji, professor of molecular biology and biochemistry. Noah Biro '09 was a co-author on a poster contributed by…
Ishita Mukerji, professor of molecular biology and biochemistry, received a $798,368 grant from the National Science Foundation for her project "Structure and Function of Holliday Junctions complexed With Proteins Probed by Fluorescence and UV Raman Spectroscopic Methods." The grant is a continuing grant which has been approved on scientific / technical merit for approximately four years. The grant will be awarded April 1.