Search Results for “naegele/”

Janice Naegele, Alan M. Dachs Professor of Science, dean of the Natural Sciences and Mathematics Division, and professor of biology, is the co-author of three recent publications. Naegele’s work focuses on stem cells and finding new treatments for epilepsy and brain damage. Naegele’s articles include the following: “Induction of temporal lobe epilepsy in mice with pilocarpine,” published by BioProtocol in February 2020. “Development of electrophysiological and morphological properties of human embryonic stem cell-derived GABAergic interneurons at different times after transplantation into the mouse hippocampus,” published by PLoS One in August 2020. “Optogenetic interrogation of ChR2-expressing GABAergic interneurons after transplantation into…

Adult neurogenesis, a process whereby new neurons are added to the brain, is thought to be confined in mammals to just a few regions, including the hippocampus, a structure important for learning. Whether this process occurs in the adult human brain is controversial, but in most other mammals that have been studied, adult neurogenesis in the hippocampus appears to be essential for forming memories. Producing new neurons in the adult hippocampus is regulated by the environment, mood, exercise, diet, and disease. In some forms of epilepsy, the production of new cells in the hippocampus, called granule cells, becomes highly abnormal and…

The Hartford Courant profiled the ground-breaking stem cell research of Laura Grabel, Lauren B. Dachs Professor of Science in Society, professor of biology, and Janice Naegle, professor of biology, professor neuroscience and behavior, as well as the work of Gloster Aaron, assistant professor of biology, assistant professor of neuroscience and behavior. Wesleyan, along with Yale University and The University of Connecticut, has received grants from the State Stem Cell Initiative, a program that allows scientists to research human stem cell lines. Grabel, Naegele and Aaron are doing research aimed at replicating cells that would ultimately help cure a form a…

Janice Naegele, chair and professor of biology, professor of neuroscience and behavior, has received a $499,988.00 grant from the Connecticut Stem Cell Research Advisory Committee for her study titled: "Brain Grafts of GABAergic Neuron Precursors Derived from Human and Mouse ES Cells for Treating Temporal Lobe Epilepsy." The four-year grant will begin in July 2009, and will support research in laboratories in Wesleyan's biology department and neuroscience program. The research is directed toward generating inhibitory interneurons that we will transplant into the hippocampus of mice that have temporal lobe epilepsy. The goal of the project is to investigate the potential…

Sitting in front of the Senate panel, Laura Grabel was ready for the “when” and “why” questions. But she knew one of these questions held a lot more potential danger to her future than the other. Grabel, the Lauren B. Dachs Professor of Science and Society, professor of biology, is a renowned stem cell researcher. She is also the co-director of the University of Connecticut Human Embryonic Stem Cell Core Facility, part of a $100 million human stem cell research initiative created by the State of Connecticut in 2006. The stem cell initiative was the state’s response to a veto…

Naegele’s Neuroscience Research Published in Journals

Naegele Lab Releases New Study on Temporal Lobe Epilepsy

Stem Cell work of Grabel, Naegele Featured

Naegele Receives Major Conn. Stem Cell Grant

Grabel Defends Embryonic Stem Cell Research to The Senate