Tag Archive for faculty publications

BIOL310 Students Collaborate on Scientific Journal Article

Twenty-three students and one faculty member are co-authors of a forthcoming manuscript in G3.

Twenty-three students and one faculty member are co-authors of a forthcoming manuscript in the journal G3.

More than 20 Wesleyan students — including three former first-years — are co-authors of a research manuscript accepted for publication in a prestigious biology research journal. The paper focuses on a species of fruit fly that has evolved, and has the ability to ingest a toxic plant.

The paper, which is forthcoming in G3: Genes | Genomes | Genetics, is the result of a study completed by BIOL310 Genomics Analysis students. Course instructor and co-author Joseph Coolon, assistant professor of biology, created BIOL310 to provide students a course-based research experience focused on measuring gene expression.

“Because the students in the course and in my lab collaborated on all the analysis, interpretation, and wrote the paper, all 23 students are co-authors of the published manuscript,” Coolon said. “G3 is a well-known and highly reputable journal for publishing in my field and I am honored to have been able to publish there, especially given the number of undergraduates that are now published authors in such a great journal.”

Volcanoes Caused Ecological Disruption Says Thomas in Nature Article

Ellen Thomas

Ellen Thomas, University Professor in the College of Integrative Sciences and research professor of earth and environmental sciences, is a co-author of a paper titled “Very Large Release of Mostly Volcanic Carbon During the Paleocene-Eocene Thermal Maximum,” published in the weekly science journal Nature on Aug. 31.

The study focused on Palaeocene–Eocene Thermal Maximum, a surface warming event associated with ecological disruption that occurred about 56 million years ago, releasing a large amount of carbon. The researchers combined boron and carbon isotope data in an Earth system model and found that the source of carbon was much larger than previously thought.

Most of the carbon, Thomas and her colleagues discovered, was probably released by volcanism during the opening of the North Atlantic Ocean when Greenland separated from Europe.

The paper also was cited in another Nature article, on PhysOrg and on Science Daily.

Knee Co-Authors Article on Hydrogen-Bonding Interactions

Joseph Knee, the Beach Professor of Chemistry and Dean of the Natural Sciences and Mathematics Division, is the author of a new article published in the journal Physical Chemistry Chemical Physics (PCCP). This “Perspectives” article, which was commissioned by the PCCP editorial board and editorial office, is a high-profile look at work by Knee and his collaborators that has been going on for nearly a decade. Perspectives articles are intended to present an authoritative state-of-the-art account of a particular research field.

The research by Knee and his collaborators, which is ongoing, uses experimental and computational methods to explore hydrogen bonding interactions, which are extremely important in the structure of water, various solutions, and in many key biochemical structures and processes.

Knee explains, “The most important aspect of our methodology is making careful experimental measurements of two single molecules forming hydrogen bonds and then modeling these bonds with modern quantum chemical calculations. The calculations allow us to decompose the various forces which contribute to the bond strength and structure. The larger goal is to generalizing this insight to more complex hydrogen bonded systems, particularly hydrogen bonding networks which exist in liquids and biological systems.”

The full article can be read here by those with subscriptions or institutional subscriptions, including those on Wesleyan’s campus.

Niraula MA ’18, Redfield Lead Team in Discovery of 3 Super-Earths

A team of scientists from Wesleyan, led by Associate Professor of Astronomy Seth Redfield and graduate student Prajwal Niraula MA’18, discovered three super-Earths transiting around a nearby star, just 98 light-years from Earth. This NASA-generated image was created to depict 55 Cancri e, a super-Earth 40 light-years away from Earth.

A team of scientists from Wesleyan discovered three super-Earths transiting around a nearby star, 98 light-years away. The NASA-generated image above depicts a different super-Earth: 55 Cancri e, discovered in 2004.

A team of scientists from Wesleyan, led by Associate Professor of Astronomy Seth Redfield and graduate student Prajwal Niraula MA ’18, has co-authored a paper on the discovery of three planets, or super-Earths, transiting around a nearby star, just 98 light-years away.

“Super-Earths are slightly larger than Earth, and the three of them straddle the divide between the rocky planets like Earth and ice giants like Neptune,” explains Redfield.

These planets were found using the Kepler Space Telescope. “Kepler has found thousands of exoplanets these last eight years, but this is the closest planetary system that Kepler has ever found, although closer planetary systems have been found using different telescopes,” says Redfield.

Hingorani, Lui, Zhou PhD ’13 Published in Biological Chemistry Journal

Three scholars from the Molecular Biology and Biochemistry Department are co-authors of a study published in The Journal of Biological Chemistry in August 2017. The paper is titled “Linchpin DNA-binding residues serve as go/no-go controls in the replication factor C-catalyzed clamp loading mechanism.”

The co-authors, Manju Hingorani, chair and professor of molecular biology and biochemistry, professor of integrative sciences; Juan Liu, research associate; and Zayan Zhou, PhD ’13, performed the study on Replication Factor C (RFC) and proliferating cell nuclear antigen (PCNA), which are two essential proteins required for DNA replication and repair in all living organisms.

The researchers found new mechanistic information about how different parts of the RFC protein work together to load PCNA onto DNA (by “clamp loading”), which allows PCNA to help dozens of other proteins to replicate and repair DNA.

The Hingorani group investigates proteins responsible for DNA replication and repair. These proteins maintain genome and cell integrity, and their malfunction leads to cancer and other diseases.

Kleinberg’s Book Argues for a Deconstructive Approach to the Practice, Writing of History

Ethan Kleinberg, director of the Center for the Humanities, is the author of Haunting History: For a Deconstructive Approach to the Past, published by Stanford University Press in August 2017.

“Haunting History is about the ways we think about the past and ‘do’ history at a moment when the digital revolution is changing how we conduct research, store materials, and even write,” Kleinberg said. “In it I argue that many of strategies for writing about, but also understanding the past, are conditioned by the analog practices of the previous century which has served to create the illusion that the past can be studied like an object held in your hand or placed under a microscope.”

The past — by definition — is gone and thus has no definite properties or perhaps we can say that is has latent properties that are activated when we do history, Kleinberg explained. “But this activation of the past is always partial leaving remains that are hidden or dormant. This is a past that is absent but haunts us and can return in ways that disturb our conventional historical narratives and understanding of what the past and history is.”

To account for this play of absence and presence, Kleinberg advocate for a “hauntological” approach to the past.

Bloom ’75, Sawhney Explore the Elm City’s Underbelly in New Haven Noir

New Haven Noir, edited by Amy BloomA star-studded cast of contributors curated by Shapiro-Silverberg Professor of Creative Writing Amy Bloom ’75 fill the pages of New Haven Noir, featuring original stories from Michael Cunningham, Stephen Carter, Roxana Robinson, Assistant Professor of English Hirsh Sawhney and many others. The book is the latest addition to an award-winning series of original noir anthologies published by Akashic Books, founded by publisher and editor-in-chief Johnny Temple ’88.

“I’m a big fan of noir,” says Bloom, editor of the anthology, which has garnered praise from both Publishers Weekly and Kirkus Reviews. “When Johnny called me and said, I don’t know if you’re from New Haven, but I know you’re connected to New Haven and I’d love you to edit the anthology, I jumped at the opportunity,” she said.

Bloom worked with Temple to select contributors for the anthology, with Bloom choosing to invite several writer friends who hadn’t written noir before, including Alice Mattison and Michael Cunningham. “I told them, it’s conflict and it’s mystery. Bleak. Snappy outfits. Great dialogue,” Bloom said. “And they said, count us in.”

In addition to serving as editor of the anthology, Bloom also is a contributor. Her story, “I’ve Never Been to Paris,” set in New Haven’s East Rock neighborhood, is actually an excerpt from a mystery she wrote years ago, tailored specifically for New Haven Noir.

Sawhney Authors E-Book on Race, Police Brutality

Hirsh Sawhney, assistant professor of English, is the author of a recent work of fiction titled The Diary of Rehan Malhotra, published as an e-book by Juggernaut Books (2017).

In this timely story, Rehan, the son of a Muslim mother and Hindu father, is a middle-aged high school teacher in New Haven, Conn., who struggles with his growing estrangement from his wife and the affluent, white community in which he lives. A charged encounter with a neighbor causes him to look back on his troubled teenage years, when he used and sold drugs, and when he forged a problematic friendship with a young black man named Ink. The Diary of Rehan Malhotra casts a spotlight on the invisible walls that divide city from suburb, which keep some people safe and others confined. It is a meditation on the possibilities and limitations of literature as a cure for social ills.

The story costs 10 rupees, or 15 cents, and is being published as a part of Juggernaut’s efforts to get inexpensive, quality literature to as diverse a readership as possible.

Sawhney is also the author of South Haven and the editor of Delhi Noir. He also collaborated with Amy Bloom ’75 on New Haven Noir, Hirsh has lived in Delhi, London and New York City.

Sawhney’s Novel Named to South Asian Literature Prize Longlist

A novel written by Hirsh Sawhney, assistant professor of English, was named to the longlist for the 2017 DSC Prize for South Asian Literature. The DSC Prize, which carries an award of $25,000, celebrates the rich and varied world of literature of the South Asian region.

In Sawhney’s South Haven (Akashic Books, 2016), grief, violence and history collide to offer a radical look at childhood and migration in suburban New England. South Haven is one of 13 books on the list. The shortlist will be announced on Sept. 27 in London.

The prize brings South Asian writing to a new global audience through a celebration of the achievements of South Asian writers, and aims to raise awareness of South Asian culture around the world.

In addition, Sawhney’s novel was shortlisted for the Shakti Bhatt First Book Award, which recognizes South Asian writing. The winner for 2017 will be announced in November.

Sawhney has lived in Delhi, India; London, U.K. and New York City. He currently lives in New Haven, Conn.

Research Paper by Personick, King Published in ‘Particle’ Journal

Michelle Personick, assistant professor of chemistry, and her graduate student Melissa King, are co-authors of a paper titled “Bimetallic Nanoparticles with Exotic Facet Structures via Iodide-Assisted Reduction of Palladium,” published in the journal Particle and Particle Systems Characterization, Vol. 34, Issue 5, in May 2017. The research was featured on the inside front cover of the issue.

In this study, Personick and King explain how gold–palladium tetradecapods (14-pointed nanoparticles) with an unusual combination of both well-defined concave and convex facets can be synthesized by introducing dilute concentrations of iodide during nanoparticle growth. Iodide directs the formation of the tetradecapods by increasing the rate of palladium ion reduction, which is a new role for this shape-controlling additive.

This article also was recently highlighted in Advanced Science News.

Mukerji, Oliver Co-Author Study in PNAS on Basic Cell Function

In this illustration, SecA is shown in light gray and the SecYEG complex is in dark gray. The rainbow colored portion of SecA is the two helix finger. n cyan is a model of the hairpin.

In this illustration, the hairpin is highlighted in cyan. The hairpin is formed by the initiator part of a protein.

All cells — bacterial or human — secrete up to 10 or 20 percent of the proteins that they make. Human secreted proteins, for example, include components of serum, hormones, growth factors that promote cell development during embryogenesis and tissue remodeling, and proteins that provide the basis for immune cell signaling during infection or when fighting cancer.

The secretion process, however, isn’t an easy feat for cells, as they need to move the proteins across a membrane through a channel. Transport requires the formation of a hairpin, formed by an initiator protein.

In a recent study, Don Oliver, the Daniel Ayres Professor of Biology, professor of molecular biology and biochemistry, and Ishita Mukerji, the Fisk Professor of Natural Science, professor of molecular biology and biochemistry, explain the importance of where and why hairpins form and how they help proteins move across the cell.

The study, titled “Alignment of the protein substrate hairpin along the SecA two-helix finger primes protein transport in Escherichia coli,” brings together key areas of membrane biochemistry, structural biology and molecular biophysics, and has innovative applications of molecular genetics and fluorescence spectroscopy. It was published in the Aug. 7 issue of Proceedings of the National Academy of Sciences (PNAS).

GLS Professor Belanger P’02 Produces Photographic Study, ‘Rift/Fault’

Photographer and author Marion Belanger P’02 explores geologic boundaries in Rift/Fault.  (Photo by Ann Burke Daly)

Graduate Liberal Studies visiting professor Marion Belanger P’02, is the author of Rift/Fault, a photographic study of the land-based edges of the North American Continental Plate. A Guggenheim Fellowship in 2002 supported a project in the Everglades, where Belanger turned her lens on both the landscape within the national park as well as the suburban development of the swamplands outside the protected area. Now, Rift/Fault continues her interest in natural land formations and boundaries—this one along the San Andreas Fault in California and the Mid-Atlantic Rift in Iceland—and the influence of human society on the earth

Published by Radius Books, and with an essay by art critic and activist Lucy R. Lippard, Rift/Fault is designed to be interactive: Open the cover and two collections of images face each other, each one bound at the top. The photographs labeled “Fault” are on the left; the right side holds “Rift,” with the reader turning each page upwards to view the image that follows. While Belanger paired the photographs on each side to be complementary, she encourages the readers to make their own pairings. The structure of the book conceptually mimics the ever-shifting tectonic plate edges, and “it gives the viewer some agency to figure out how they want to view the book and, by default, how they want to see the landscape. The work itself is a cultural study,” she says.