Olivia DrakeThree Wesleyan students were accepted into the American Society for Biochemistry and Molecular Biology Honor Society. The students are Lee Gottesdiener '12, Sophia Levan '12 and Alejandra Olvera '12. These outstanding students have been selected based on their academic achievements, their commitment to research and science outreach. The American Society for Biochemistry and Molecular Biology (ASBMB) is a nonprofit scientific and educational organization with more than 12,000 members. Founded in 1906, the Society is based in Rockville, M.D. The Society's purpose is to advance the science of biochemistry and molecular biology through publication of scientific and educational journals: the Journal of Biological…
A research group led by Manju Hingorani, associate professor of molecular biology and biochemistry, has published eight papers in 2011-2012 on the mechanisms of DNA replication and repair proteins, independently and in collaboration with research groups at Wesleyan and other national and international universities. The papers are: "Large conformational changes in MutS during DNA scanning, mismatch recognition and repair signaling," published in The EMBO Journal, 2012 (in press). "The Variable Sub-domain of Escherichia coli SecA functions to regulate in the SecA ATPase Activity and ADP release," published in the Journal of Bacteriology, 2012 (March 2 Epub). Don Oliver, the Daniel Ayres Professor of…
"Drug Design from Transition State Analysis" will be the central topic of the 12th annual Molecular Biophysics and Biological Chemistry Retreat Sept. 22. The public is invited to the retreat, which will be held at Wadsworth Mansion in Middletown. Faculty from chemistry, physics and biology will present lectures. (more…)
Ishita Mukerji, professor of molecular biology and biochemistry, director of graduate studies, is the co-author of "“HU Binding to a DNA Four-Way Junction Probed by Förster Resonance Energy Transfer," published in Biochemistry, issue 50, pages 1432–1441, 2011. This work specifically examines the Escherichia coli protein HU's four-way junction interaction using fluorescence spectroscopic methods. This work was supported by grants from the National Science Foundation and the Patrick and Catherine Weldon Donaghue Medical Research Foundation.
Eric GershonIn a newly published paper, Rich Olson, assistant professor of molecular biology and biochemistry, describes studies of a toxin produced by the bacterium that causes cholera. The paper –“Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins” – is the culmination of nearly eight years work. Co-authored with Swastik De, a graduate student in Olson’s lab, the paper has been published online by Proceedings of the National Academy of Sciences (PNAS) and will appear in a print edition later this spring. Olson’s lab studies the molecular details of how pathogens invade human hosts. Bacteria produce toxins to…
Ishita Mukerji, professor of molecular biology and biochemistry, and dean of the Natural Sciences and Mathematics division, received a grant for $6,750 from the National Sciences Foundation. The grant is part of the National Science Foundation's Research Experiences for Undergraduates, which provides funding for faculty to work with an undergraduate student. The award is supporting research on “Structure and Function of Holliday Junctions Complexed with Proteins Probed by Flourescence and UV Raman Spectroscopic Methods.”
Q: Maureen, you are an accounting specialist for the Molecular Biology and Biochemistry Department, and an administrative assistant for the Wesleyan Howard Hughes Medical Institute (HHMI) Program in the Life Sciences. Is it challenging to wear two hats? A: Maybe it should be more of a challenge, but I’ve been doing it so long it’s become second nature. I akin it to speaking two languages, your brain just shifts automatically from one to the other. Michael Weir (director of the Hughes Program) in one door to talk summer applications and Mike McAlear (chair of the Molecular Biology and Biochemistry Department) walks in…
Manju Hingorani, associate professor of molecular biology and biochemistry, received a $165,038 grant from the Connecticut Department of Health to support her project titled “DNA Mismatch Repair in Tobacco Smoke Medicated Cancer.” The project will be funded for 18 months.
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Michael McAlear, chair and associate professor of molecular biology and biochemistry, and James Arnone, a Ph.D candidate in his lab, have published “Adjacent Gene Pairing Plays a Role in the Coordinated Expression of Ribosome Biogenesis Genes MPP10 and YJR003C in Saccharomyces Cerevisiae” a paper that shows that the physical position of genes on chromosomes -- immediately adjacent gene pairs in particular -- plays an important role in how they are turned on and off. These findings were first discovered in yeast cells, but also hold true over a wide range of life forms, from worms to fruit flies to humans.…
Manju Hingorani, associate professor of molecular biology and biochemistry, and Jacob Bricca, adjunct assistant professor of film studies, explained their experimental cross-disciplinary course on science documentary filmmaking at Wesleyan in a December 2010 article published in American Society for Biochemistry and Molecular Biology (ASBMB) Today. In the article, Hingorani and Bricca wrote about their course, "Making the Science Documentary," which they co-taught together, starting in 2007. The course was designed to introduce undergraduate students to the life sciences and to documentary filmmaking (more…)
Manju Hingorani, associate professor of molecular biology and biochemistry, received a $165,083 grant from the Connecticut Department of Health for her study titled “Role of DNA Mismatch Repair in Tobacco Smoke-Mediated Carcinogenesis.” The grant will fund a post-doc and research associate’s projects through September 2012. Also, Hingorani, received a $497,532 grant from the National Institutes of Health for her study titled “PCNA Clamp Mechanisms in DNA Replication and Repair.” The grant will fund graduate and undergraduate students’ research projects through June 2013. The project is supported by Award number R15GM094047 from the National Institute of General Medical Sciences. Also, Hingorani…