Tag Archive for Biology

Sultan, Baker ’18, Berg ’16 Coauthor Paper on Plant Development

Sonia Sultan, professor of biology and professor, environmental studies, and her former students Brennan Baker BA/MA ’18 and Lars Berg ’16 are the coauthors of a paper published in the August 2018 issue of Frontiers in Plant Science.

The study, “Context-Dependent Developmental Effects of Parental Shade Versus Sun Are Mediated by DNA Methylation,” presents work that Baker completed as a BA/MA student in 2017–18. The article is part of a special Frontiers theme on the emerging area of ecological epigenetics.

In this study, the coauthors compared the development of individual plants when their parents were grown in shade or in full sun. The results show that genetically identical seedlings developed very differently just as a result of this difference in parental conditions.

Baker followed up this finding in several ways, including showing that this ‘neo-Lamarckian’ effect on development was conveyed from parents to offspring through epigenetic regulatory changes to DNA expression rather than changes in the genes themselves.

“Learning how environmental effects in the parent generation can influence offspring via these epigenetic mechanisms is one of the most astonishing and important new areas in biology since it challenges the long-held view that only DNA sequence information could be inherited,” Sultan explained.

Baker will be pursuing his work on transgenerational environmental effects in a different biological context. This fall, he is starting an environmental health PhD program at Columbia University, where he plans to study inherited effects of environmental contaminants on human health. Since graduating from Wesleyan, Berg has held a competitive NIH research internship and is planning to go on to medical school.

In addition, a paper by Baker, Sultan, Maya Lopez-Ichikawa ’18, and Robin Waterman ’19 was an invited submission for a special issue of Philosophical Transactions of the Royal Society that is dedicated to adaptive responses to rapid environmental change. The paper is currently under review for publication.

Wesleyan’s Natural History Collection and Curiosities Featured in Usdan

The exhibit "Shelving the History of Life" will be featured inside the display cases in Usdan Universiy Center throughout the fall semester. The true-to-scale exhibit showcases specimens curated, restored, prepared, and documented from the Joe Webb Peoples Museum of Natural History, the former Wesleyan Museum, and other collections on campus.

The exhibit “Shelving the History of Life” will be featured in the display case in Usdan University Center until fall recess. The exhibit showcases specimens curated, restored, and documented from the Joe Webb Peoples Museum of Natural History, the former Wesleyan Museum, and other collections on campus.

In 1870, Orange Judd bequeathed Wesleyan $100,000 to build Judd Hall, which was designed as a building for the study of natural sciences. Included with this building was the Wesleyan Museum, which housed a prominent natural history collection containing over 300,000 specimens.

In 1957, the museum was closed and specimens were donated to other museums, put into storage in various places on campus, or “temporarily” loaned to local schools. In 1970, before the current museum reopened in Exley, the collection stored in the tunnels under Foss Hill was found to have been severely vandalized, with many specimens lost, stolen, or irreparably damaged.

Within the last two years, several Wesleyan faculty, students, and staff have exhumed thousands of these misplaced artifacts and are working to bring them back for public viewing. A new exhibit in Usdan, “Shelving the History of Life,” showcases many of these once-lost, and now found, relics of Wesleyan’s natural history collections.

“This exhibit is a showcase of the spectrum of natural history objects remaining in our collections, including taxidermy specimens, a wide range of wet specimens preserved in alcohol, skeletons, seashells, fossils, and minerals,” explained Andy Tan ’21, who is one of the cocurators of the exhibit.

Sultan Delivers Lectures around the World

Sonia Sultan, right, is presented with a plaque by Ellen Harrison, wife of the influential biologist Rick Harrison after whom the Harrison Keynote Lecture is named. Sultan presented the lecture at Cornell's annual Evo Day symposium in May.

Sonia Sultan, right, receives a plaque from Ellen Harrison, wife of the influential biologist Rick Harrison after whom the Harrison Keynote Lecture is named. Sultan presented the lecture at Cornell’s annual Evo Day symposium in May.

This spring, Sonia Sultan, professor of biology, professor of environmental studies, has delivered several notable invited talks in different parts of the world.

In February, she presented the annual Darwin Day talk at the University of Glasgow in Scotland. Sultan was the first woman scientist to present this prestigious lecture, in which a prominent evolutionary biologist shares their research and its broader implications. Sultan spoke on “Eco-Devo Insights to Evolutionary Questions,” using results from her Wesleyan lab’s plant research to address basic questions about individual development, inheritance, and adaptation. She was also interviewed about her contributions to current evolutionary biology for the University of Glasgow’s Institute of Biodiversity, Animal Health & Comparative Medicine podcast, Naturally Speaking.

In April, Sultan also gave a research seminar in Mexico City at the National University of Mexico’s Institute for Ecology, and in March, she presented her work to philosophers of biology at a European Union–sponsored conference in London.

Finally, on May 10, Sultan delivered the Harrison Keynote Lecture at Cornell’s annual “Evo Day” evolutionary biology symposium. The lecture is named in honor of Rick Harrison, an influential and much admired evolutionary biologist who served on the Cornell faculty until his death in 2016. Sultan’s next speaking event will be to give the closing lecture at a September meeting on “Advances in Evolutionary Biology” at the Max Planck Institute for Evolutionary Biology in Plön, Germany.

Students Inducted into Honor Society, Present Research at American Society for Biochemistry and Molecular Biology Meeting

Undergraduates from the Biology, Chemistry, and Molecular Biology and Biochemistry majors showed off their science at the 2018 meeting of the American Society for Biochemistry and Molecular Biology. From Left, Alex Shames '18 (MacQueen Lab), BA/MA student Arden Feil (MacQueen Lab), Will Barr '18 (Weir Lab), Christine Little '18 (Mukerji Lab), Cody Hecht '18 (Taylor Lab), and Emily Kessler '18 (Hingorani Lab).

Undergraduates from the biology, chemistry, and molecular biology and biochemistry majors showed off their science at the 2018 meeting of the American Society for Biochemistry and Molecular Biology. From left, Alex Shames ’18 (MacQueen Lab), Arden Feil BA/MA ’18 (MacQueen Lab), Will Barr ’18 (Weir Lab), Christine Little ’18 (Mukerji Lab), Cody Hecht ’18 (Taylor Lab), and Emily Kessler ’18 (Hingorani Lab).

Seven Wesleyan students recently were inducted into the American Society for Biochemistry and Molecular Biology (ASBMB) Honor Society, and many of them presented research posters at the ASBMB annual meeting in San Diego, April 21–25.

The ASBMB Honor Society recognizes exceptional undergraduate juniors and seniors who are pursuing a degree in the molecular life sciences for their scholarly achievement, research accomplishments, and outreach activities. The Wesleyan students inducted were Will Barr ’18, Alexa Strauss ’19, Emily Kessler ’18, Christine Little ’18, Julie McDonald ’18, Rubye Peyser ’18, and Alexander Shames ’18.

The following students attended the annual meeting:

• Kessler, whose poster was titled, “Investigating the Mechanistic Basis of Mutant MutS DNA Repair Protein Malfunction in Lynch Syndrome”
• Barr, “An mRNA-rRNA base pairing model for efficient protein translation”
• Little, “Investigation into the Binding Interactions of Saccharomyces cerevisiae Histone H1 with Holliday Junction”
• Shames, “The Long and Short of Synaptonemal Complex Assembly: Investigating the genesis and functional relevance of a smaller Zip1 isoform”
• Cody Hecht ’18, “Escherichia coli Heptosyltransferase I: Examining Protein Dynamics with Pyrene Excimer Fluorescence and Tryptophan-Induced Quenching”
• Arden Feil BA/MA ’18, “Scraping the Tip of Zip1’s Role in Meiotic Chromosome Dynamics: Using lacO/LacI corecruitment to identify crossover promoting factors that interface with the N-terminus of a synaptonemal complex protein”

“It was a joy to present the research that I’ve been working on for the past two years as a part of Wesleyan’s Beckman Scholars Program,” said Barr. “Science research can seem like a roller coaster at times, and presenting my research in the company of scientists at all levels of their careers helped me remember just how thrilling this process has been.”

The mission of ASBMB is to advance the science of biochemistry and molecular biology through organization of scientific meetings, advocacy for funding of basic research and education, support of science education at all levels, promotion of the diversity of individuals entering the scientific workforce, and publication of a number of scientific and educational journals, including the Journal of Biological Chemistry and the Journal of Lipid Research.

Wesleyan in the News


In this recurring feature in 
The Wesleyan Connection, we highlight some of the latest news stories about Wesleyan and our alumni.

 

 

Recent Wesleyan News

  1. Hartford Courant“Connecticut Natives at Wesleyan Organize TEDx Conference”

Wesleyan hosted its inaugural TEDx conference on April 7, featuring talks by many distinguished alumni, local officials, and others. Two of the student organizers, Eunes Harun ’20 and Leo Marturi ’20, are interviewed about the event.

2. The Hill: “Trump, Pelosi Appear Most in Early Ads—for the Other Side” 

A new analysis from the Wesleyan Media Project finds that Donald Trump has been the top target of political attack ads this year, with Nancy Pelosi the second favorite target, as both parties seek to drive their political bases to the polls. “Although presidents and presidential candidates are the most common targets in congressional campaign ads, it is noteworthy that Pelosi has consistently been singled out more than any other congressional leader since 2010 despite her minority party status for the bulk of that time,” said Erika Franklin Fowler, associate professor of government and WMP co-director.

3. Faith Middleton Food Schmooze: “Funeral Food with a Twist, a Seductive Rosé and Amy Bloom”

In connection with her new book, White Houses, Shapiro-Silverberg Professor of Creative Writing Amy Bloom talks about food in the Franklin Roosevelt White House. Bloom comes in around 21 minutes.

4. Naturally Speaking: “Extending Evolution, an Interview with Prof. Sonia Sultan”

On this podcast, Sonia Sultan, professor of biology, professor of environmental studies, discusses her research on phenotypic plasticity and transgenerational effect in plants, and shares her thoughts on one of most controversial ideas currently circulating in mainstream evolutionary biology: the so-called “extended evolutionary synthesis.” Sultan was honored at the University of Glasgow’s Institute of Biodiversity, Animal Health & Comparative Medicine’s annual Darwin Day lecture.

5. Inside Higher Ed: “The Data Should Make You Happy!”

President Michael Roth ’78 reviews Steven Pinker’s new book, Enlightenment Now: The Case for Reason, Science, Humanism, and Progress. Roth writes: “We don’t need cheerleading psychologists telling us we should be happier than we are.”

6. Squash Magazine: “Teaching the Game: Women and Squash”

Shona Kerr, Wesleyan’s head coach of men’s and women’s squash, is interviewed for a story about gender bias in the world of squash coaching. Kerr is one of only three women in the country who coaches a men’s collegiate squash team.

Recent Alumni News

  1. NDTV Profit: “Wipro Director, Harvard Alumnus Rishad Premji [’99] Appointed Chairman Of Nasscom” Rishad Premji, who was an economics major at Wesleyan and holds an MBA from Harvard, was appointed chairman of IT industry body Nasscom (National Association of Software and Service Companies) for 2018–19. Previously, he was chief strategy officer and board member of Wipro Ltd, which he joined in 2007. In 2014 he was named a Young Global Leader by the World Economic Forum. [See the site for a video message from Premji, on accepting this new position.]

2. NPR: “Mary Halvorson [’02] Re-Engineered Jazz Guitar. Now, She’s Hacking Her Own Code”

In this review of Halvorson’s new double album, Code Girl, Nate Chinen, director of editorial comment at NPR Music, calls Halvorson’s style “staunchly unplaceable in style—art-rock? avant-prog?—and mysterious in several other respects.” The article also refers to John Spencer Camp Professor of Music, Emeritus, Anthony Braxton as her “august mentor.” Code Girl is out on the Firehouse 12 label.

3. Harvard Medical School News: “Why the Fly? Geneticist Stephanie Mohr [’93] Delves into Science’s Favorite Winged Model Organism”

“[S]elf-described ‘fly person’ Stephanie Mohr,” a lecturer on genetics at Harvard Medical School and author of the book First in Fly: Drosophila Research and Biological Discovery (Harvard University Press, 2018)explains her fascination with the insect and its importance in genetics research.

4. New York Times: “Even With Scholarships, Students Often Need Extra Financial Help“

This article by Janet Morrissey profiles a number of programs at prestigious universities that are designed to assist low-income scholarship students with living expenses. Richard Locke ’81, provost at Brown University, is mentioned as “help[ing] prepare Brown’s E-Gap (Emergency, Curricular and Co-curricular Gap) Funds, and its FLi (First Generation Low-Income) Center in late 2015 after hearing stories from students who were struggling financially.”

5. WBAL 1090—Educator Beverly Daniel Tatum [’75, P’04, Hon. ’15] to Speak at Towson Commencement

WBAL NewsRadio 1090’s Tyler Waldman reported Towson University President Kim Schatzel said: “We are honored to welcome Beverly Daniel Tatum to campus as our commencement speaker. Not only is she a thought leader in the higher education community, her expertise in diversity, inclusion and race relations supports Towson University’s relentless pursuits in these areas.” Tatum will speak at Towson’s College of Liberal Arts commencement on May 23, 2018, and will receive an honorary doctorate. A former Wesleyan trustee, Tatum was awarded an honorary doctorate from Wesleyan in 2015.

Naegele in The Conversation: Are Neurons Added to the Human Brain after Birth?

Jan Naegele is one of 19 women faculty in the country to receive a Drexel Fellowship.

Jan Naegele

Wesleyan faculty frequently publish articles based on their scholarship in The Conversation US, a nonprofit news organization with the tagline, “Academic rigor, journalistic flair.” Janice Naegele, the Alan M. Dachs Professor of Science, writes about the implications of a controversial new neuroscience study from the University of California, San Francisco. Naegele also is professor of biology and professor of neuroscience and behavior. Read her bio on The Conversation.

Scientists have known for about two decades that some neurons—the fundamental cells in the brain that transmit signals—are generated throughout life. But now a controversial new study from the University of California, San Francisco, casts doubt on whether many neurons are added to the human brain after birth.

BIOL310 Students Collaborate on Scientific Journal Article

Twenty-three students and one faculty member are co-authors of a forthcoming manuscript in G3.

Twenty-three students and one faculty member are co-authors of a forthcoming manuscript in the journal G3.

More than 20 Wesleyan students — including three former first-years — are co-authors of a research manuscript accepted for publication in a prestigious biology research journal. The paper focuses on a species of fruit fly that has evolved, and has the ability to ingest a toxic plant.

The paper, which is forthcoming in G3: Genes | Genomes | Genetics, is the result of a study completed by BIOL310 Genomics Analysis students. Course instructor and co-author Joseph Coolon, assistant professor of biology, created BIOL310 to provide students a course-based research experience focused on measuring gene expression.

“Because the students in the course and in my lab collaborated on all the analysis, interpretation, and wrote the paper, all 23 students are co-authors of the published manuscript,” Coolon said. “G3 is a well-known and highly reputable journal for publishing in my field and I am honored to have been able to publish there, especially given the number of undergraduates that are now published authors in such a great journal.”

Oppenheim ’02 Urges Cooperation, Preparation for Pandemic Threats

Ben Oppenheim ’02, a senior fellow at the Center on International Cooperation, as well as a consulting scientist with the start-up Metabiota, writes about the importance of international collective action for pandemic preparedness.

Ben Oppenheim ’02, a consulting scientist with Metabiota, a start-up focusing on epidemiological modeling and epidemic risk preparedness, was recently invited to participate in a workshop at the National Academy of Medicine. As a result, Oppenheim and his colleagues wrote an article published in Lancet Global Health titled “Financing of International Collective Action for Epidemic and Pandemic Preparedness,” based on these meetings. Also writing for the Brookings Institution, Oppenheim further explored the challenges of responding to global outbreaks, offering a four-point plan to protect the global poor during pandemics, with co-author Gavin Yamey.

“Post-Ebola and Zika, there’s been increasing worry—and debate—about how to prepare for epidemics and pandemics that threaten global health,” notes Oppenheim, who is also a senior fellow and visiting scholar at New York University’s Center on International Cooperation. “Cracking the problem means thinking through the ways that policy, economics, health, and other factors all intertwine. In the workshop, we were thinking about how to build incentives to improve disease surveillance and outbreak detection, as well as how to improve the legal and economic architecture to speed up the development of vaccines and therapeutics. All of this demands attention to everything from epidemiology, to financing, and to politics.”

Oppenheim also discussed the economic impacts of pandemics,

Biology Team Samples Drought-Tolerant Bacteria in Death Valley

Nicole DelGaudio ’18 samples the rhizospheres of a juniper tree at about 7,000 feet above sea level.

Nicole DelGaudio ’18 samples the rhizosphere of a juniper tree.

This spring, a research team from Wesleyan traveled to Death Valley National Park to explore the ways bacteria diversifies in extreme environments.

Death Valley, located about 130 miles west of Las Vegas, is a below-sea-level basin known for being the hottest place on earth and driest place in North America. The average rainfall is less than 2 inches, annually.

“National parks are ideal for research, in general, because the land is protected indefinitely from commercial development,” said team leader Fred Cohan, professor of biology, professor of environmental studies. “Death Valley is a nice model system for exobiology because of its extreme habitat.”

Cohan, along with graduate student Jerry Lee, Bella Wiener ’19 and Nicole DelGaudio ’18, traveled to California May 29 through June 4. During this time, the researchers trekked through miles of parched — and often prickly — landscapes seeking to sample root soil, or rhizosphere, from various plant species, each over a wide range of elevations that differ notably in their temperatures.

Sultan Delivers Talks on New Approaches to Evolution

Sonia Sultan

Sonia Sultan

Sonia Sultan, professor of biology, professor of environmental studies, presented the keynote address at the 2017 Diebold Symposium, held at Kalamazoo College, April 27-29. Her talk was titled “Plant Environmental Response: A Weedy Answer to 3 Big Questions.” In the keynote talk, Sultan presented findings from her Wesleyan research group and discussed their implications for heredity and evolution.

In mid-May, Sultan will join an invited group of 16 biologists and philosophers at the Konrad Lorenz Institute in Vienna, Austria, for discussions of causality in evolutionary biology. The workshop is part of an international consortium of researchers and philosophers funded by the J.H. Templeton Foundation to develop an expanded conceptual framework for evolution. Following the workshop, Sultan will spend several days at the University of Lund in Sweden, as a seminar speaker and guest scientist.

StemCONN Symposium Shows Connecticut is Leader in Stem Cell Research

Stephen Devoto, professor of biology, professor of neuroscience and behavior, spoke on “A Protection Racket: Tbx6 and the Establishment of Muscle Stem Cells in the Zebrafish Embryo” during the StemConn 2017 conference, held April 27 in New Haven, Conn.

Professor Stephen Devoto spoke at the StemConn 2017 conference, held April 27 in New Haven, Conn.

The annual StemCONN conference, held April 27 in New Haven, made clear that Connecticut’s commitment to stem cell research has helped the state become a national leader in this burgeoning area of research and commercial development.

Wesleyan is one of the founders of the StemCONN conference, along with Yale and the University of Connecticut. This year marks the 6th StemCONN conference, an event that brings together more than 500 individuals from academic institutions, bioscience industry, and government.

“Stem cell research continues to be an exciting and fast-paced field with new discoveries fueling prospects for new therapies based on regenerative medicine for a range of debilitating medical conditions, and Connecticut is at the leading edge of this field,” said Janice Naegele, professor of biology and one of the symposium’s organizers. “A major emphasis of StemConn’s mission is education, and this year’s conference attendees included undergraduate trainees, graduate students, and postdoctoral fellows. Special interactive sessions over lunch provided a fabulous small group format for undergraduate and graduate students to ask questions and discuss career paths with our invited speakers. This is a one of a kind opportunity for many of our trainees.”

Connecticut passed ground-breaking legislation in 2005, becoming the first state to fully approve funding for stem cell research. The 12-year, $100-million per year initiative has enabled the state to compete successfully for scientific talent in the field and has helped to establish a growing bioscience corridor in the Hartford-New Haven area.