Tag Archive for Weir

NIH to Support Weir’s Research on Ribosome Protein Translation

Michael Weir

Michael Weir

Michael Weir, professor of biology, professor of integrative sciences, received a grant worth $491,599 from the National Institutes of Health in September. Weir will use the award to better understand how ribosomes — the machines that make proteins — choose sequences in mRNAs (messenger ribonucleic acids) to start protein translation.

“This is an ongoing challenge in biology and is of great importance for investigations of cell function,” Weir said.

Weir is testing the hypothesis that sequences downstream of the translation start codon of mRNAs can form transient base pairs with a conserved sequence in 18S ribosomal RNA (called the 530 loop). This ribosomal RNA sequence is part of the structure of the ribosome and is located in the ribosome entrance tunnel for mRNAs.

He proposes that the base pairing is like a car’s braking system that helps the ribosome pause at the start codon, and that the transient base pairing also helps the ribosome walk along the mRNA in three-nucleotide steps as it adds amino acids to the growing new protein chain.

NIH Supports Weir’s Research on Translation Initiation of Yeast

Michael Weir, director of the Hughes Program in the Life Sciences, professor of biology, received a grant worth $328,200 from the National Institutes of Health on Sept. 19. Weir will use the funds to support a study titled, “Proteomic Analysis of Translation Initiation of Yeast,” through August 2011.

 

NSF Grant Improves Numerical Modeling Capacity at Wesleyan

Francis Starr, associate professor of physics, co-authored a grant proposal, which was recently funded by the NSF to support growth of the computer facilities for the university’s Scientific Computing and Informatics Center.

A $298,736 grant from the National Science Foundation (NSF) will allow Wesleyan to remain competitive in numerical modeling research and education on an international level.

Francis Starr, associate professor of physics, David Beveridge, the Joshua Boger University Professor of the Sciences and Mathematics, and Michael Weir, professor of biology, director of the Hughes Program in the Life Sciences, received the grant for a project titled “Major Research Instrumentation – Recovery and Reinvestment program (MRI-R2): Acquisition of Shared Cluster and Database Computing Facilities at Wesleyan University.”

The grant, awarded over three years beginning May 1, will fund growth of the computer facilities for the university’s Scientific Computing and Informatics Center (SCIC), including expansion of the university’s high-performance computer cluster and a new genomics database server.

Wesleyan currently runs 36 Dell computer nodes for the academic computing cluster known as “Swallowtail.” Each machine is capable of processing eight jobs simultaneously, for a total of 288 jobs. Another 129 computer nodes called “Sharptail,” recently donated by Blue Sky Studios, are capable of processing two jobs simultaneously each, for a total of 258 jobs.

“With the NSF grant, we anticipate roughly doubling our capacity,” Starr says. “Think of it as setting up a virtual laboratory in the computer where we can perform experiments that might be challenging

NSF Grant Funds Cluster, Database Facilities

Francis Starr, associate professor of physics; David Beveridge, the Joshua Boger University Professor of the Sciences and Mathematics; and Michael Weir, professor of biology, director of the Hughes Program in the Life Sciences, received a grant from the National Science Foundation for a project titled “MRI-R2: Acquisition of Shared Cluster and Database Computing Facilities at Wesleyan University.” The grant, worth $298,736, will be awarded over three years beginning May 1, 2010. The grant was awarded as part of the American Recovery and Reinvestment Act of 2009.