On Nov. 1, neuroscience and biology BA/MA graduate student Helen Karimi presented a Graduate Speaker Series talk titled "All good things come in pairs: Uncovering the activity of BcnI through co-localization microscopy." Karimi's talk focused on restriction endonucleases (REases), a large family of enzymes that make sequence-specific cuts in DNA. As her abstract details, type IIP REases usually cleave sequences as homodimers. However, BcnI, an enzyme belonging to this subtype, acts in a different way. Karimi's work aims to observe the fine details of BcnI’s cleavage mechanism by using Total Internal Reflection Fluorescence (TIRF) microscopy, an imaging technique in which…