Chemistry

For many of the faculty members retiring from Wesleyan this year, representing over two centuries of academic experience, the joy of their time at the University comes down to their work with students. Amy B. Bloom '75, Shapiro-Silverberg Professor of Creative Writing; Stephen Henri Devoto, professor of biology; Fred M. Ellis, professor of physics; Janice R. Naegele, Alan M. Dachs Professor of Science; Stewart E. Novick, Joshua Boger University Professor of the Sciences and Mathematics; Irina M. Russu, E. B. Nye Professor of Chemistry; and Peter Gordon Solomon, adjunct professor of physical education announced their retirements and will receive emeritus…

Michael Greenberg ’76, P’14 is one of three winners of the Lundbeck Foundation’s The Brain Prize 2023—the largest personal award for neuroscience research—for his contributions to the field. Greenberg, the Nathan Marsh Pusey Professor of Neurobiology at Harvard Medical School, said it was “very gratifying” for his life’s work to be recognized by neuroscientists at the highest level. He has spent more than four decades researching the brain, specifically neuroplasticity—the ability of the brain to change in response to learning, experience, or following injury. “It's also been gratifying to see the work come to fruition in ways that we think…

Assistant Professor of Chemistry Alison O’Neil’s most recent research has drawn a direct parallel between a pesticide commonly used from the late 1940s through the late 1970s and instances of amyotrophic lateral sclerosis (ALS), according to a paper published in the journal ACS Chemical Neuroscience on December 13. Cis-chlordane was banned in 1988 in the United States, but it can still be found in the environment. “We find that human stem-cell-derived motor neurons are more sensitive to (the pesticide) cis-chlordane than other cell types and their action potential dynamics are altered … Together, our work points to cis-chlordane as a potential sporadic…

A new Wesleyan research project will explore the possibility that more chemical elements than previously thought could be used to help create inexpensive and renewable energy storage technologies. Associate Professor of Chemistry Michelle Personick’s lab was the recipient of a three-year grant from the U.S. Department of Energy to encourage research into clean-energy technologies and low carbon manufacturing. Researchers at 54 universities and 11 National Laboratories received awards in late August. Platinum group elements (PGE) like platinum, palladium, and rhodium are crucial in the production of many energy storage technologies, like fuel cells and the sustainable production of liquid fuel…

Recent research by Erika A. Taylor, associate professor of chemistry, suggests that the way scientists have long believed some antibiotics used to treat bacterial infections work could be incorrect. Aminoglycoside antibiotics have broad-spectrum, bacterial killing abilities and are often prescribed for childhood infections caused by Gram-negative bacterial pathogens, which can be found in E. coli, Salmonella, and V. cholera, amongst others. The stakes of the research are real, Taylor explained. Improved antibiotics would prevent needless deaths from E. coli, Salmonella and other Gram-negative bacteria. Relatively simple treatments, such as those for urinary tract infections, would be more efficient, improving people’s…

Erika Taylor, associate professor of chemistry, didn’t have a single female science teacher during her academic career. The lack of female representation in the field had an impact on her journey. “I had to swim upstream the whole time. That is what it felt like,” Taylor said. In an effort to make sure other young women don’t feel the same way, Taylor and Meng-ju Renee Sher ‘07, assistant professor of physics, are working diligently to show girls that a life in the sciences is desirable and attainable. The Girls in Science program, a partnership between Wesleyan and the Middletown Public…

At first glance, a viewer sees a single image of pink-tinted cubes, resembling a bacteria culture from high school biology. But upon closer examination, the viewer begins to see a series of other shapes—triangles to hexahedrons to tetahexahedraons (cubes with four-sided pyramids on each face). "If you stare at this image for a while, you can see that it's actually a series of five images in the top row, and five images on the bottom row, and each of these images show us nanoparticles that are made of gold and copper," said Brian Northrop, professor of chemistry. "It's intriguing, captivating,…

When launching spacecrafts and missiles, small navigational mistakes could lead to catastrophic results. A satellite could spin completely out of orbit, a missile could mistakenly strike a civilian territory, or a spaceship could end up at another planet altogether. Three Wesleyan researchers are collaborating on the development of a novel sensor that would benefit navigation and several other applications. The new, hypersensitive acceleration sensor is based on a principle borrowed from nuclear physics and has been developed at Wesleyan. It provides enhanced sensitivity and precision compared to conventional sensors. "Our underlying concept can be applied in a variety of sensing…

Erika Taylor, associate professor of chemistry, recently co-authored three papers and a book chapter related to (1) biomass to biofuel production and (2) development of new therapeutics to treat Gram-negative bacterial infections. Taylor's work investigates problems at the biological chemistry interface and seeks to find applications of her work to the fields of medicine and sustainable energy. Her chapter called “Lignin Enzymology – Recent Efforts to Understand Lignin Monomer Catabolism” in the book Comprehensive Natural Products III: Chemistry and Biology, and her paper “Identifying Metabolic Pathway Intermediates that Modulate Enzyme Activity: A Kinetic Analysis of the DesB Dioxygenase from Sphingobium…

Joy Cote PhD ’18, Cody Hecht '18, MA'19, and Erika Taylor, associate professor of chemistry, are the co-authors of a study that explores how opposite charges on our substrate and enzyme cause a protein to change shape when the substrate binds. The study, titled "Opposites Attract: Escherichia coli Heptosyltransferase I Conformational Changes Induced by Interactions between the Substrate and Positively Charged Residues," appears in the February 2020 issue of Biochemistry. "If you can imagine how the opposite charges of magnets are attracted toward each other, then you understand the results of this paper," Taylor explained. "The enzyme uses positively-charged amino…

Erika Taylor, associate professor of chemistry, is honored for being among the "Top 35 Women in Higher Education" in the March 20 issue of Diverse. Taylor joined the Wesleyan faculty in 2007 and teaches courses in the areas of organic chemistry, biochemistry, environmental chemistry, and bio-medicinal chemistry, among others. She's also associate professor, environmental studies, and associate professor, integrative sciences, and takes a multidisciplinary approach to investigating problems at the biological chemistry interface. Diverse acknowledged Taylor for "striv(ing) to find ways to exploit enzymes found in nature to perform reactions that can help advance the fields of chemistry and medicine."…

On Sept. 26, the Molecular Biophysics Program hosted its 20th Annual Molecular Biophysics Retreat at Wadsworth Mansion in Middletown. Several Wesleyan faculty, students, and guests attended the all-day event, which included five talks, two poster sessions, and a reception. Lila Gierasch, Distinguished Professor of Biochemistry and Molecular Biology and Chemistry at the University of Massachusetts, Amherst, delivered the keynote address, titled "Hsp70s: Allosteric Machines that Perform a Multitude of Cellular Functions." Gierasch, a leader in the field of protein folding, is a newly elected member of the National Academy of Sciences. Her work focuses particularly on folding in the cell…

Seven Faculty Members Announce Retirements

Michael Greenberg ’76, P’14 Wins The Brain Prize 2023 for Neuroscience Research

Research Shows Pesticide Could be Connected to ALS

New Research to Help Create Renewable Energy Storage

New Research Questions Efficacy of Some Antibiotics

Wesleyan Partners With Middletown Public Schools to Encourage Girls in Science

Scientific Images of Nanoparticles, Colliding Stars, Learned Words Win Annual Contest

Faculty Collaborate on New, Patent-Pending, Hypersensitive Accelerometer

Taylor Co-Authors 3 Articles, Writes Book Chapter on Lignin Enzymology

Cote PhD ’18, Hecht MA ’19, Taylor Co-Author New Paper in Biochemistry

Taylor Named a “Top 35 Woman in Higher Education” by Diverse

Molecular Biophysics Program Hosts 20th Annual Retreat