Olivia DrakeManju Hingorani, visiting scholar in molecular biology and biochemistry, and Brandon Case PhD '19 are co-authors of a new study published in Proceedings of the National Academy of Sciences USA in July 2020. The paper, titled “Recurrent mismatch binding by MutS mobile clamps on DNA localizes repair complexes nearby," reports novel findings about the mechanism whereby MutS protein triggers initiation of DNA repair. The research at Wesleyan was supported by NIH grant R15 GM114743 awarded to Manju Hingorani. Case is currently a postdoctoral fellow at Harvard Medical School. Jennifer Tucker, associate professor of history, discusses the role of material culture and visual…
For demonstrating exceptional achievement in academics, undergraduate research, and science outreach, the American Society for Biochemistry and Molecular Biology inducted Tenzin Ngodup '20, Meera Joshi '20, and Charya Khun '20 into the ASBMB Honor Society, ΧΩΛ. ΧΩΛ recognizes exceptional undergraduate juniors and seniors pursuing degrees in the molecular life sciences at colleges or universities. To be eligible, undergraduate nominees must be members of an ASBMB student chapter, and maintain a minimum of a 3.4 GPA on a 4.0 scale. Nominations may be submitted by either a faculty ASBMB member or by the student member. Ngodup, Joshi, and Khun are among only…
Three Wesleyan faculty recently received Academic Research Enhancement Awards (R15) from the National Institutes of Health (NIH). R15 grants stimulate research at educational institutions that provide baccalaureate training for a significant number of the nation's research scientists, but that have not been major recipients of NIH support. Awards provide funding for small-scale, new, or ongoing health-related meritorious research projects, enhancing the research environment at eligible institutions and exposing students to research opportunities. Amy MacQueen, associate professor of molecular biology and biochemistry, received a $492,900 award on Aug. 7 for her research titled "How do Synaptonemal Complex Proteins Mediate the Coordinated?" MacQueen…
On Sept. 26, the Molecular Biophysics Program hosted its 20th Annual Molecular Biophysics Retreat at Wadsworth Mansion in Middletown. Several Wesleyan faculty, students, and guests attended the all-day event, which included five talks, two poster sessions, and a reception. Lila Gierasch, Distinguished Professor of Biochemistry and Molecular Biology and Chemistry at the University of Massachusetts, Amherst, delivered the keynote address, titled "Hsp70s: Allosteric Machines that Perform a Multitude of Cellular Functions." Gierasch, a leader in the field of protein folding, is a newly elected member of the National Academy of Sciences. Her work focuses particularly on folding in the cell…
The Summe Program for Research in the Sciences culminated with a research poster session in the lobby of Exley Science Center, with more than 100 students participating. The program, held May 29 to July 26, was open to frosh, sophomores and juniors currently enrolled at Wesleyan. Wesleyan science faculty members served as mentors for student research in their laboratories. In addition to the closing poster session, the students participated in weekly seminars and workshops, a symposium, and various social events. After the poster session, students displayed their posters in the hallways outside the introductory biology laboratories. (more…)
(Story by Kerisha Harris) For the sixth year in a row, the weeklong Wesleyan Girls in Science Summer Camp welcomed dozens of middle school-aged girls for a week of learning, exploration, and STEM-centered fun. From Aug. 5-9 inside Exley Science Center, the 32 campers in grades 4-6 spent the week learning about everything from how to extract DNA from a strawberry, to the parts of the brain, and even how to make (but don’t touch) an ice-cold comet. By Friday, the young scientists were excited to share all they had learned with their friends and families, and did so through a poster presentation and…
On May 25, members of the Class of 2019 were inducted into Wesleyan’s Gamma Chapter of Phi Beta Kappa Society, the oldest national scholastic honor society. The Wesleyan Gamma Chapter was organized in 1845 and is the ninth-oldest chapter in the country. To be elected, a student must first have been nominated by the department of his or her major. The student also must have demonstrated curricular breadth by having met the General Education Expectations and must have achieved a GPA of 93 and above. Phi Beta Kappa is the oldest surviving Greek letter society in America, founded in December…
Meera Joshi ’20 is the recipient of an American Society for Biochemistry and Molecular Biology (ASBMB) Undergraduate Research Award for her work on the DNA mismatch repair system. The $1,000 award will support her research titled "Exploring the Dynamics of Msh2-Msh6 Binding to Holliday Junction Through ATPase Activity. Her advisor is Ishita Mukerji, professor of molecular biology and biochemistry. Joshi's research focuses on a DNA mismatch repair protein called Msh2-Msh6 that initiates the repair of DNA mismatches after replication in eukaryotes. This is a highly conserved process from bacteria to humans and has implications for human health. "We are particularly interested in…
Molecular biology and biochemistry graduate student Brandon Case and Professor Manju Hingorani are coauthors of a study published in Nucleic Acids Research in March 2019. The paper, titled “The ATPase mechanism of UvrA2 reveals the distinct roles of proximal and distal ATPase sites in nucleotide excision repair,” reports new findings on how the UvrA2 protein uses its ATPase activity to probe DNA for damage lesions, such as those caused by UV radiation, and initiate nucleotide excision repair (NER). This DNA repair process corrects tens of thousands of lesions introduced daily into the human genome by UV rays and chemical agents. (more…)
Two Wesleyan students were inducted into the 2019 American Society for Biochemistry and Molecular Biology (ASBMB) Honor Society in March. They are among only 33 students from around the country who were eligible to join the society this year. The inductees, Mackenzie Mitchell '20 and Edelina (Lina) Marzouk '19 are both majoring in molecular biology and biochemistry and the Science in Society Program. They are both members of the ASBMB Student Chapters, have a GPA of over 3.4 on a 4.0 scale, and have demonstrated exceptional achievement in academics, undergraduate research, and science outreach. The students were recognized by the Molecular Biology &…
Molecular biology and biochemistry graduate student Brandon Case and Manju Hingorani, professor of molecular biology and biochemistry, are coauthors on a study published in Nucleic Acids Research in October 2018. The paper, titled “Coordinated protein and DNA conformational changes govern mismatch repair initiation by MutS,” reports new findings on how the Mutator S (MutS) protein repairs mistakes in the DNA sequence, which is essential for maintaining the accuracy of the genetic code. The collaborative effort from researchers at Wesleyan, the University of North Carolina at Chapel Hill, and North Carolina State University employed single molecule and ensemble kinetic methods to…