Naegele, Aaron, Student Researchers Published in <em>Journal of Neuroscience</em>

Jan Naegele, Gloster Aaron and several Wesleyan researchers are the co-authors of an article titled "Long-Term Seizure Suppression and Optogenetic Analyses of Synaptic Connectivity in Epileptic Mice with Hippocampal Grafts of GABAergic Interneurons," published in the October 2014 edition of The Journal of Neuroscience, Issue 34(40): 13492-13504. Naegele is professor of biology, professor of neuroscience and behavior, and director of the Center for Faculty Career Development. Aaron is associate professor of biology, associate professor of neuroscience and behavior. The article is co-authored by Diana Lin '15; graduate students Jyoti Gupta and Meghan Van Zandt; recent alumni Elizabeth Litvina BA/MA '11, XiaoTing Zheng '14, Nicholas Woods '13 and…

Janice Naegele, professor of biology, professor of neuroscience and behavior, director of the Center for Faculty Career Development, was awarded a $250,000 grant in September from CURE Epilepsy.org. The grant, which will be given over a period of three years, will fund research examining synaptic function in GABAergic stem cell transplants using optogenics. This technique provides a way to modulate and control the activity of individual neurons in living tissue using discrete delivery of light into the brain or tissue slice. It will be used to investigate how GABAergic stem cell transplants suppress seizures in mice with temporal lobe epilepsy.…

Jan Naegele, professor of biology, professor of neuroscience and behavior, made two presentations in 2013. On March 12, she spoke on "Promises and Pitfalls of Stem Cell Therapy for Brain Disorders" at the 17th Annual Meeting for the Israeli Society for Biological Psychiatry in Kibbutz Hagoshrim, Israel. On March 26, she spoke to the Middlesex Elderly Service Providers on "Stem Cell Therapy for Brain Disorders" in Middletown. On June 11, Naegele will speak on "GABAergic interneuron replacement for temporal lobe epilepsy" at the University of California-Irvine.

Jan Naegele, professor of biology, professor of neuroscience and behavior, was named a 2013-14 ELATE (Executive Leadership in Academic Technology and Engineering) at Drexel® Fellow for the 2013-14 academic year. Naegele and 18 other women faculty in science, technology, engineering and math fields, received the fellowship. They come from a range of universities and colleges across the country, many with global experience. The ELATE at Drexel® Fellow program focuses on increasing personal and professional leadership effectiveness, leading and managing change initiatives within their institutions, using strategic finance and resource management to enhance the missions of their organizations, and creating a…

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Janice Naegele, professor of biology, professor of neuroscience and behavior, received a $484,788 National Institutes of Health Academic Research Enhancement Award for her work on “Stem Cell Transplation for Epilepsy" in 2013.

Janice Naegele will become director of the Center for Faculty Career Development on July 1. Naegele, professor of biology, professor of neuroscience and behavior, has served as chair of the Biology Department, and has served on the Educational Policy Committee, Review and Appeals Board, the Graduate Liberal Studies Advisory Committee, the Life Sciences Building Committee, and the Writing Certificate Committee. She has published extensively in the areas of developmental neurobiology, stem cells and translational rodent models of neurological disorders. Her research explores genetic, small molecule, and neural stem cell based treatments for cognitive disabilities and epilepsy. She currently serves on…

Janice Naegele, professor of biology, professor of neuroscience and behavior, and Laura Grabel, the Lauren B. Dachs Professor of Science and Society, professor of biology, were recently honored in Hartford Magazine’s “Amazing Women” issue. Two of only 13 women selected this year for recognition, Naegele and Grabel were lauded for their contributions to the field of stem cell research. The magazine's profile of Naegele states: "The research conducted by Janice Naegele, who is professor of biology and neuroscience and behavior at Wesleyan University, is opening up new possibilities for treating epilepsy through stem cell therapy. Her work focuses on temporal lobe epilepsy,…

For the roughly one-third of temporal lobe epilepsy patients for whom drugs are not an option, researchers at Wesleyan are paving the way for alternative therapies using stem cells. Faculty members Janice Naegele, Gloster Aaron and Laura Grabel, together with Xu Maisano, Ph.D. ’11, Elizabeth Litvina, B.A. ’10/M.A. ’11, and Stephanie Tagliatela, the lab manager in the Naegele lab, recently published a landmark study in the Journal of Neuroscience on the use of embryonic stem cells to treat temporal lobe epilepsy (TLE). The researchers derived neural “parent cells” in culture from mouse embryonic stem cells, and transplanted them into the…

An article written by three Wesleyan faculty and two alumni was published in the January 2012 issue of the Journal of Neuroscience, 32(1): pages 46-61. In "Differentiation and functional incorporation of embryonic stem cell derived GABAergic interneurons in the dentate gyrus of mice with temporal lobe epilepsy," the authors describe embryonic stem cell derived neuronal transplants for treating temporal lobe epilepsy. The authors include Jan Naegele, professor of biology, professor of neuroscience and behavior; Gloster Aaron, assistant professor of biology, assistant professor of neuroscience; Laura Grabel, the Lauren B. Dachs Professor of Science and Society, professor of biology; Xu Maisano Ph.D. '11; and Elizabeth…

[youtube width="640" height="420"]http://www.youtube.com/watch?v=49QKAlwdq8s[/youtube] Q: Mary, what is your class year, and what are you majoring in? A: I'm a junior, and I'm double-majoring in neuroscience and behavior and English. Q: You’re currently working in the lab of Jan Naegele, professor of neuroscience and behavior, professor of biology. Can you tell us a bit about your research in the Naegele Lab? A: The Naegele Lab studies temporal lobe epilepsy (TLE), which involves instances of elevated electrical activity in the brain called seizures. In cases where medication does not alleviate seizures, TLE patients experience cell death and damage in the dentate gyrus,…

“Let’s pass around the brains, but please be careful,” Jennifer Cheng '11 says. “They break easily.” Maryann Platt ’11 and Mandela Kazi ’12 hand out the brains, detailed plastic models with interlocking, removable pieces that allow anyone picking them up to study the organ’s specific areas. “I don’t think you need to use the stands,” says Janice Naegele, professor of biology, professor of neuroscience and behavior. “I think you can just give them the brains.” The students nod and make a note and return to their presentation, titled “The Human Connectome Project,” which focuses on the brain, connectomes and the new…

Naegele, Aaron, Student Researchers Published in Journal of Neuroscience

Naegele Awarded Grant from CURE Epilepsy.org

Naegele Speaks on “Promises and Pitfalls on Stem Cell Therapy for Brain Disorders”

Naegele Named 2013-14 ELATE at Drexel® Fellow

Wesleyan Scientists Attend Connecticut Stem Cell Symposium

Naegele Received NIH Award for Epilepsy Research

Naegele to Direct Center for Faculty Career Development

Naegele, Grabel Lauded for Stem Cell Research Contributions

Future Stem Cell-based Therapies for Treating Epilepsy Explored in 3 Biology Labs

Naegele, Aaron, Grabel, Xu ’11, Litvina ’11 Published in Journal of Neuroscience

Vallo ’13 Studies Seizure Suppression, Teaches Local Students about Science

Neuroscience and Behavior Capstone Focuses on Service