62 search results for "naegele"

StemCONN Symposium Shows Connecticut is Leader in Stem Cell Research

Stephen Devoto, professor of biology, professor of neuroscience and behavior, spoke on “A Protection Racket: Tbx6 and the Establishment of Muscle Stem Cells in the Zebrafish Embryo” during the StemConn 2017 conference, held April 27 in New Haven, Conn.

Professor Stephen Devoto spoke at the StemConn 2017 conference, held April 27 in New Haven, Conn.

The annual StemCONN conference, held April 27 in New Haven, made clear that Connecticut’s commitment to stem cell research has helped the state become a national leader in this burgeoning area of research and commercial development.

Wesleyan is one of the founders of the StemCONN conference, along with Yale and the University of Connecticut. This year marks the 6th StemCONN conference, an event that brings together more than 500 individuals from academic institutions, bioscience industry, and government.

“Stem cell research continues to be an exciting and fast-paced field with new discoveries fueling prospects for new therapies based on regenerative medicine for a range of debilitating medical conditions, and Connecticut is at the leading edge of this field,” said Janice Naegele, professor of biology and one of the symposium’s organizers. “A major emphasis of StemConn’s mission is education, and this year’s conference attendees included undergraduate trainees, graduate students, and postdoctoral fellows. Special interactive sessions over lunch provided a fabulous small group format for undergraduate and graduate students to ask questions and discuss career paths with our invited speakers. This is a one of a kind opportunity for many of our trainees.”

Connecticut passed ground-breaking legislation in 2005, becoming the first state to fully approve funding for stem cell research. The 12-year, $100-million per year initiative has enabled the state to compete successfully for scientific talent in the field and has helped to establish a growing bioscience corridor in the Hartford-New Haven area.

2017 McNair Fellows Present Research Projects in Senior Talks

The Senior McNair Fellows who spoke on April 18 are part of the cohort of 10 who are presenting their undergraduate research projects this year. From left to right: Nicholas Morgan ’17 (majoring in economics), Stacy Uchendu (majoring in chemistry), Hanna Morales Hernandez (majoring in chemistry) , and Cindy Flores (majoring in earth and environmental science).

The Senior McNair Fellows who spoke on April 18 are part of the cohort of 10 who are presenting their undergraduate research projects this year. From left to right: Nicholas Morgan ’17 (majoring in economics), Stacy Uchendu (majoring in chemistry), Hanna Morales Hernandez (majoring in chemistry) , and Cindy Flores (majoring in earth and environmental science).

This spring, the 10 McNair Fellows of the Wesleyan Class of  2017 are presenting their undergraduate research projects at Senior Talks on Thursdays at noon from April 18 through May 4, in Allbritton 311. The presentations describe the research that students have conducted with Wesleyan faculty mentors. Many of these projects also are the subject of student theses or final papers presented for the Wesleyan BA requirements.

The Wesleyan University Ronald E. McNair Post Baccalaureate Achievement Program, established in 2007, assists students from underrepresented groups with preparing for, entering, and progressing successfully through postgraduate education by providing guidance, research opportunities, and academic and financial support to students planning to pursue PhDs. Junior and Senior Fellows do research with faculty mentors and participate in

Naegele Named a 2017 ‘Women of Innovation’ by the Connecticut Technology Council

Jan Naegele accepts her Women of Innovation® award.

Jan Naegele accepts her “Women of Innovation” award.

The Connecticut Technology Council recently selected Professor Janice Naegele as a 2017 “Women of Innovation.”

Naegele, professor of biology, professor of neuroscience and behavior, was honored during the “Women of Innovation” awards dinner, held March 29 in Plantsville, Conn. The award recognizes women accomplished in science, technology, engineering, math and those who are involved in their community.

Naegele is a developmental neuroscientist whose research seeks to identify novel treatments for epilepsy and brain damage. She has published extensively on applications of stem cell transplantation for neural repair, including articles on embryonic stem cell therapy for treating epilepsy and the synaptic mechanisms underlying seizure suppression by fetal inhibitory neuron transplants. In the Naegele Laboratory, a team of graduate students, working with undergraduates and technicians, investigates the therapeutic effects of stem cell transplantation through experimental approaches including behavior, electrophysiology, immunohistochemistry, viral-mediated gene overexpression and optogenetics.

The Connecticut Technology Council received more than 200 nominations for the Women of Innovation® awards. Nagele was one of three women named a finalist in the Academic Innovation and Leadership-College category.

Wesleyan’s Antonio Farias, vice president for equity and inclusion; Joyce Jacobsen, provost and vice president for academic affairs; Ishita Mukerji, the Fisk Professor of Natural Science, professor of molecular biology and biochemistry; and Joe Knee, dean of the Natural Sciences and Mathematics division, professor of chemistry, nominated Naegele for the award.

From left, Antonio Farias, Ishita Mukerji, Jan Naegele, Joyce Jacobsen and Joe Knee attended the Connecticut Technology Council Women of Innovation® awards dinner on March 29.

From left, Antonio Farias, Ishita Mukerji, Jan Naegele, Joyce Jacobsen and Joe Knee attended the Connecticut Technology Council’s “Women of Innovation” awards dinner on March 29.

“I’m very grateful to my Wesleyan colleagues who nominated me for this award,” Naegele said. “The award was unexpected and a wonderful honor.”

Naegle, who came to Wesleyan in 1991, has served as chair of the Biology Department, director of the Center for Faculty Career Development, and as vice chair of the faculty. Her work is funded by the Connecticut Regenerative Medicine Research fund, the National Institutes of Health, and CURE Epilepsy. Recent honors and awards include the Louise Hansen Marshall Mentoring Award from the Society for Neuroscience; election to the Connecticut Academy of Science and Engineering; and completing a one-year fellowship in the ELATE at Drexel women’s executive leadership program.

Read more News @ Wesleyan articles about Professor Naegele.

 

Naegele Teaches Neuroscience to Tibetan Buddhist Monks

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In June, Jan Naegele, professor of biology, professor of neuroscience and behavior, traveled to Mundgod, India to teach Tibetan monks through the Emory-Tibet Science Initiative (ETSI), a program promoting “the convergence of science and spirituality as two complementary systems of knowledge,” according to the Emory Tibetan Partnership. ETSI was founded as a pilot in 2006 by Emory University at the bequest of the 14th Dalai Lama. Naegele’s journey, which she took together with her husband, Dr. Paul Lombroso, was described in the Winter 2016 issue of Rutland Magazine, in an article featuring many photographs provided by Naegele.

Naegele Co-Authors New Paper in Nature Communications

Jan Naegele is one of 19 women faculty in the country to receive a Drexel Fellowship.

Jan Naegele

Janice Naegele, professor of biology, professor of neuroscience and development, is the co-author of a new paper titled, “Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement.” It was published in Nature Communications on June 1.

Brain malformations called focal cortical dysplasia are typically formed during human embryonic cortical development and are a common cause of drug-resistant epilepsy and cognitive impairments. One of the causes of cortical dysplasia is improper migration of developing cortical neurons. Failure to reach their correct destinations in the cerebral cortex and dysregulated growth leads to the formation of growths or tubers in regions of cerebral cortex. These abnormal growths don’t wire up properly with other cortical neurons and exhibit seizure activity. In this multi-lab collaborative study, the researchers show in mice with experimentally-generated cortical malformations that there is an increase in growth-associated signaling molecules in experimentally-generated cortical tubers associated with seizures. Blocking this signaling cascade with the molecule rapacycin from early stages can prevent the neuronal misplacement, tuber-like growths, and seizures, but once rapamycin is discontinued, the seizures return. Despite the adverse side-effects of taking rapamycin, these findings suggest that life-long treatment with rapamycin may be required in individuals with focal cortical dysplasia, in order to prevent the re-occurrence of seizures and tubers.

The paper is co-authored with Felicia Harrsch, Naegele’s former lab manager, and researchers at the Yale University School of Medicine.

Support Wesleyan Researchers in Crowdfunding Pilot

Four Wesleyan academic departments, from psychology to dance to chemistry to biology, are competing for grant funds through a new crowdfunding site specifically designed for research project fundraising.

experimentExperiment.com’s Challenge Grant for Liberal Arts Colleges asked scientists to define a scientific research question for the crowd with a prize for the project with the most backers. The pilot launched on Feb. 24 and concludes March 25.During this 31-day period, the goal is to reach $4,000 in funding. If so, the team is granted the money. If not, they receive nothing and no one’s pledges are charged. By backing a project, participants will receive updates, results and data from project creators.

Wesleyan research include how the brain prevents risky-decision making/addiction; the effects of using artificial sweeteners; controlling seizures with light; and the effectiveness of somatic mind-body practices on victims of the war.

On Wednesday, March 16 at 11:59 p.m., Experiment will award the project with the most backers $2,000 directly through their project page.

Wesleyan’s projects include:

High School Student, Mentored by Wesleyan Neuroscience Program, Finalist for Research Prize

Jan Naegele is one of 19 women faculty in the country to receive a Drexel Fellowship.

Jan Naegele

A high school student from New York, who is mentored by a faculty member and a graduate student in Wesleyan’s Neuroscience and Behavior Program, is one of the top four finalists for the Neuroscience Research Prize, awarded by the American Academy of Neurology and the Child Neurology Society.

As a recipient of the prize, Armonk, N.Y. resident Ryan Infante will receive a $1,000 cash prize and per diem for expenses at the 45th Annual Meeting of the Child Neurology Society in Vancouver, B.C. in October 2016. He will present his stem cell transplantation research during the Child Neurology Society meeting.

Infante, currently a senior at Byram Hills High school in Armonk, N.Y., completed this research last summer while working with Janice Naegele, professor of biology, professor of neuroscience and behavior, and graduate student Dan Lawrence, a BA/MA who majored in neuroscience and behavior in 2015.

Infante was initially guided by his high school science teacher to carry out extensive reading and research about neuroscience.

“When he first contacted me, as a sophomore in high school, he had already read 12 journal articles and had written a review paper that he presented to his science class,” Naegele said. “He became fascinated by work on stem cell transplantation to repair the hippocampus in rodent models of epilepsy and he wanted to learn more about the types of neurons that we study, which utilize the neurotransmitter GABA.”

Throughout his junior year of high school, Infante and Naegele corresponded over email and held frequent Skype discussions. And last summer, Naegele welcomed him to Wesleyan to conduct research in her lab. Infante, at that time, had read many papers on a method called CLARITY—a new way to make brains transparent—to allow scientists to peer into the center of the brain.

Infante worked with Naegele and Lawrence to collect a large number of embryonic and postnatal brains from transgenic mice expressing fluorescent proteins that light up developing and migrating GABAergic interneurons in the embryonic brain.

“When Ryan came to my lab, he and Dan made careful observations of the gradual clearing of the tissue and the process of making opaque brains transparent,” Naegele said.

Infante learned how to use a 3-D printer to make special chamber slides to hold the embryonic brains for microscopy.

“This was a clever modification of the protocol and with this modification, Dan and Ryan examined the brains and also modified protocols for doing additional fluorescent stains in the intact brain tissue,” she said.

Over the past 25 years as a faculty member at Wesleyan, Naegle has welcomed 10 high school students for a summer research project. Most of them are still in science–either attending graduate school, medical school or combined programs. Among them is Elizabeth “Lizzie” Paquette ’16, who ended up matriculating to Wesleyan and is currently a triple major in computer science, mathematics and neuroscience.

“I am so impressed by the capacity for high school students to carry out innovative research with our own Wesleyan students and I’m very proud of both Ryan and Dan,” said Naegele.

Infante was admitted early decision to the University of Pennsylvania, and Lawrence is working on his master’s thesis, and plans to apply to medical school next year.

Naegele Honored by Society for Neuroscience

Janice Naegele accepting the award at the Society for Neuroscience's annual meeting.

Janice Naegele accepting the award at the Society for Neuroscience’s annual meeting.

During the Society for Neuroscience‘s (SfN) annual meeting Oct. 17-21, Janice Naegele, professor of biology, professor of neuroscience and behavior, received the Louise Hansen Marshall Special Recognition Award.

The Louise Hanson Marshall Special Recognition Award honors individuals who have significantly promoted the professional development of women in neuroscience through teaching, organizational leadership, public advocacy and more. Naegele shares the 2015 Louise Hansen Marshall award with Paul Greengard P’77, P’79, GP ’08, the Vincent Astor Professor at The Rockefeller University in New York.

Naegele began her career studying the characteristics of cortical neurons and more recently has performed pioneering studies of transplantation of inhibitory neurons in the brain as a potential treatment for severe epilepsy.

Students Share Summer Research at Poster Session

On July 30, Wesleyan’s Summer Research Poster Session took place at Exley Science Center. More than 110 undergraduate research fellows from Math and Computer Sciences, Astronomy, Physics, Chemistry, Molecular Biology and Biochemistry, Biology, Earth and Environmental Sciences, the Quantitative Analysis Center, and Psychology presented research at the event. (Photos by Laurie Kenney)

Aidan Bardos ’17 presented her research titled "The Effects of Nutrition on the Immune Response of Wooly Bear Caterpillars Infected by Parasitoid Wasps." Bardos' faculty advisor is Michael Singer, associate professor of biology and environmental studies.

Aidan Bardos ’17 presented her research titled “The Effects of Nutrition on the Immune Response of Wooly Bear Caterpillars Infected by Parasitoid Wasps.” Bardos’ faculty advisor is Michael Singer, associate professor of biology and associate professor of environmental studies.

A poster titled "Immunohistochemical Analysis of Status Epilepticus Mice Treated with Striatal-Enriched Tyrosine Phosphatase Inhibitor" was presented by Matt Pelton ’17. His advisor is Janice Naegele, professor of biology, professor of neuroscience and behavior.

A poster titled “Immunohistochemical Analysis of Status Epilepticus Mice Treated with Striatal-Enriched Tyrosine Phosphatase Inhibitor” was presented by Matt Pelton ’17. His advisor is Janice Naegele, professor of biology, professor of neuroscience and behavior.

Wesleyan Faculty Organize, Speak at StemCONN 2015

Gloster Aaron, associate professor of biology, associate professor of neuroscience and behavior, spoke at StemCONN 2015 in April.

Gloster Aaron, associate professor of biology, associate professor of neuroscience and behavior, spoke at StemCONN 2015 in April.

Wesleyan faculty members played key roles in StemCONN 2015, Connecticut’s stem cell and regenerative medicine conference, held April 27 in Hartford, Conn.

Janice Naegele, professor of biology, professor of neuroscience and behavior, director of the Center for Faculty Career Development, served on the conference’s organizing committee for the second time this year.

Gloster Aaron, associate professor of biology, associate professor of neuroscience and behavior, spoke at the conference on “Investigating how transplants reduce seizures: brain slice electrophysiology and ontogenetic stimulation of transplanted cells.” He discussed the collaborative work being done by his lab and those of Naegele and Laura Grabel, the Lauren B. Dachs Professor of Science and Society, professor of biology, which aims to heal damaged areas of the brain that are the source of seizures in temporal lobe epilepsy by providing newborn neurons to those areas. The goal is for the newborn neurons to replace dead neurons and repair broken neuronal circuits that are thought to be a cause of temporal lobe epilepsy.

Nearly 500 scientists, business leaders and students attended the event, which is held every two years. The event was also attended by many Connecticut officials, including Gov. Dannel Malloy, U.S. Sen. Chris Murphy, U.S. Congresswoman Rosa DeLauro, Connecticut State Rep. Lonnie Reed, and Hartford Mayor Pedro Segarra. The conference was sponsored by Wesleyan, as well as Yale University, the University of Connecticut, the Connecticut Academy of Science and Engineering, Yale-New Haven Hospital, the City of Hartford, and other companies and non-profit organizations.

GRAMMY Foundation Grant Supports Loui’s Research on Epilepsy Intervention

Psyche Loui uses equipment like EEG to run experiments on music perception and cognition.

Psyche Loui uses equipment like EEG to run experiments on music perception and cognition. (Photo by Olivia Drake)

Psyche Loui, assistant professor of psychology, assistant professor of neuroscience and behavior, was awarded a grant of $20,000 in March from the GRAMMY Foundation Grant Program to study a musical biofeedback-based intervention for epilepsy.

The grant will fund three different studies that combine EEG sonification, translational research and basic neuroscience for this type of intervention. Loui anticipates that the results will apply music technology as a possible solution to a neurological disorder affecting 65 million people worldwide.

Loui noted that for the approximately one-third of patients with epilepsy who don’t respond well to seizure medication,

Faculty, Students Invited to Workshops on Contemplative Pedagogy Feb. 19

How do faculty help students, and themselves, thread a path through an ever-growing body of information? What practices can faculty and students find that enable them to bring a clear and sustained focus to their work in the classroom and the laboratory?

Through two workshops and discussions, held Feb. 19, participants can consider how one might approach teaching from a contemplative perspective, in both the long and short term. Faculty and students will experiment with the adaptation of several traditional contemplative practices to classroom situations including “stilling” (breath and body awareness), contemplative writing, “beholding,” and explore how these might be instantiated in a classroom, laboratory or personal practice.

Michelle Francl

Michelle Francl

Michelle Francl, professor of chemistry on the Clowes Fund for Science and Public Policy at Bryn Mawr College, will lead the workshops along with Wesleyan faculty and staff. Francl is a quantum chemist who has published in areas ranging from the development of methods for computational chemistry to the structures of topologically intriguing molecules. She takes a contemplative approach to both, introducing students to practices to help them find stillness and focus, including contemplative writing, and feels strongly that a pedagogical stance that recognizes the role contemplation plays in research and writing — scientific or otherwise — has the potential to deepen students engagement in their work.

“Studies show that contemplative pedagogy – a teaching method to integrate secular meditation and mindfulness into the classroom – can help improve cognitive and academic performance,”