Jan Naegele, professor of biology, professor of neuroscience and behavior, is the author of “Tangled Roots: Digging Deeper into Astrocyte or Interneuron Dysfunction in Temporal Lobe Epilepsy,” published in Epilepsy Currents, Volume 11, Issue 1, 2011. The article is online here.
She’s also the author of “STEP Regulation of Seizure Thresholds in the Hippocampus,” published in Epilepsia by Wiley Publishers, 2011. The article is online here.
The March 2011 cover of Epilepsia.
Faculty, alumni and students from the Biology Department and Neuroscience and Behavior Department have an article titled “STEP regulation of seizure thresholds in the hippocampus,” published in Epilepsia, Volume 52, Issue 3, March 2011. Epilepsia is the journal of the International League Against Epilepsy.
The paper’s co-authors include Gloster Aaron assistant professor of biology, assistant professor of neuroscience and behavior; Janice Naegele, professor of biology, professor of neuroscience and behavior; Stephen Briggs BA ’07, MA ’08, Jeffrey Walker BA ’08, MA ’09, and biology Ph.D. candidate Kemal Asik. Paul Lombroso, a professor at Yale University, contributed to the report.
This study found that mice lacking a specific enzyme (STEP) have a significantly heightened resistance to developing epileptic seizures. The study then documents a mechanism and location in the brain where this enzyme might have its effect in regulating the seizure thresholds. Briggs and Walker were BA/MA students in the NS&B program, and they worked in the labs of Naegele and Aaron, respectively. Asik works with John Kirn, chair of the Neuroscience and Behavior Department.
Janice Naegele, professor of biology, professor of neurosceince and behavior, and a group of Wesleyan students attended the Connecticut Forum on “The Glorius, Mysterious Brain” Feb. 25 at the Bushnell Theater in Hartford, Conn. The Connecticut Forum is a nationally recognized, nonprofit organization that offers live, unscripted panel discussions among renowned experts and celebrities, and community outreach programs. Nagele’s group listened to Autism advocate Temple Grandin, author and Harvard professor Steven Pinker and cognitive scientist Paul Bloom.
In addition, Michael Greenberg ’76, chair of neurobiology at Harvard Medical School, spoke to Naegele’s students about “experience-dependent changes in gene expression.”
Stephen Devoto, associate professor of biology, associate professor of neuroscience and behavior, is featured in a video created by a student enrolled in the course, Making the Science Documentary.
Manju Hingorani, associate professor of molecular biology and biochemistry, and Jacob Bricca, adjunct assistant professor of film studies, explained their experimental cross-disciplinary course on science documentary filmmaking at Wesleyan in a December 2010 article published in American Society for Biochemistry and Molecular Biology (ASBMB) Today.
In the article, Hingorani and Bricca wrote about their course, “Making the Science Documentary,” which they co-taught together, starting in 2007. The course was designed to introduce undergraduate students to the life sciences and to documentary filmmaking
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Jan Naegele, professor of biology, professor of neuroscience and behavior, received a $100,000 from the National Institute of Mental Health for her research on “Molecular and Cellular Analysis of Brand-Enriched PTPs.” The grant will be awarded through March 2010. This is a renewal of a previous grant, which is subcontracted with Yale University.
Laura Grabel, the Lauren B. Dachs Professor of Science and Society, professor of biology, and Jan Naegele, professor of neuroscience and behavior, professor of biology, are the co-authors of “Migration of transplanted neural stem cells in experimental models of neurodegenerative diseases,” published in Stem Cells and Regenerative Medicine by Springer/Humana Press, 2010.
Janice Naegele, professor of biology, professor of neuroscience and behavior, is the co-author of “Gene and stem cell therapies for treating epilepsy,” published in Epilepsy: Mechanisms, Models, and Translational Perspectives, Dekker M, Inc., 2010; “Migration of transplanted neural stem cells in models of neurodegenerative diseases,” published in Stem Cells and Regenerative Medicine by Springer Science (Humana Press, 2010; “Westward Ho! Pioneering mouse models for X-linked infantile spasms syndrome,” published in Epilepsy Currents 10(1): 1-4, 2010; “Trekking through the telencephalon: hepatocyte growth factor-mediated guidance for parvalbumin-expressing interneurons,” published in Epilepsy Currents 10(4), 2010; and “Transplants for brain repair in epilepsy and neurodegenerative diseases,” published in Neuropharmacology 58: 855-864, 2010.